Eric Fischer, PhD

Assistant Professor of Biological Chemistry and Molecular Pharmacology, Dana-Farber Cancer Institute
A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader.
Authors: Authors: Huang HT, Dobrovolsky D, Paulk J, Yang G, Weisberg EL, Doctor ZM, Buckley DL, Cho JH, Ko E, Jang J, Shi K, Choi HG, Griffin JD, Li Y, Treon SP, Fischer ES, Bradner JE, Tan L, Gray NS.
Cell Chem Biol
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Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C.
Authors: Authors: Zeng M, Lu J, Li L, Feru F, Quan C, Gero TW, Ficarro SB, Xiong Y, Ambrogio C, Paranal RM, Catalano M, Shao J, Wong KK, Marto JA, Fischer ES, Jänne PA, Scott DA, Westover KD, Gray NS.
Cell Chem Biol
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pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase.
Authors: Authors: An J, Ponthier CM, Sack R, Seebacher J, Stadler MB, Donovan KA, Fischer ES.
Nat Commun
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Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosome.
Authors: Authors: Cavadini S, Fischer ES, Bunker RD, Potenza A, Lingaraju GM, Goldie KN, Mohamed WI, Faty M, Petzold G, Beckwith RE, Tichkule RB, Hassiepen U, Abdulrahman W, Pantelic RS, Matsumoto S, Sugasawa K, Stahlberg H, Thomä NH.
Nature
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Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations.
Authors: Authors: de Wispelaere M, Du G, Donovan KA, Zhang T, Eleuteri NA, Yuan JC, Kalabathula J, Nowak RP, Fischer ES, Gray NS, Yang PL.
Nat Commun
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Structural basis of lenalidomide-induced CK1a degradation by the CRL4(CRBN) ubiquitin ligase.
Authors: Authors: Petzold G, Fischer ES, Thomä NH.
Nature
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Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6.
Authors: Authors: Jiang B, Wang ES, Donovan KA, Liang Y, Fischer ES, Zhang T, Gray NS.
Angew Chem Int Ed Engl
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SPLINTS: small-molecule protein ligand interface stabilizers.
Authors: Authors: Fischer ES, Park E, Eck MJ, Thomä NH.
Curr Opin Struct Biol
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Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models.
Authors: Authors: Silva MC, Ferguson FM, Cai Q, Donovan KA, Nandi G, Patnaik D, Zhang T, Huang HT, Lucente DE, Dickerson BC, Mitchison TJ, Fischer ES, Gray NS, Haggarty SJ.
Elife
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Functional regulation of the DNA damage-recognition factor DDB2 by ubiquitination and interaction with xeroderma pigmentosum group C protein.
Authors: Authors: Matsumoto S, Fischer ES, Yasuda T, Dohmae N, Iwai S, Mori T, Nishi R, Yoshino K, Sakai W, Hanaoka F, Thomä NH, Sugasawa K.
Nucleic Acids Res
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