Karen Adelman, PhD

Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing.
Authors: Authors: Etchegaray JP, Zhong L, Li C, Henriques T, Ablondi E, Nakadai T, Van Rechem C, Ferrer C, Ross KN, Choi JE, Samarakkody A, Ji F, Chang A, Sadreyev RI, Ramaswamy S, Nechaev S, Whetstine JR, Roeder RG, Adelman K, Goren A, Mostoslavsky R.
Mol Cell
View full abstract on Pubmed
Non-coding RNA: More uses for genomic junk.
Authors: Authors: Adelman K, Egan E.
Nature
View full abstract on Pubmed
Pausing of RNA polymerase II disrupts DNA-specified nucleosome organization to enable precise gene regulation.
Authors: Authors: Gilchrist DA, Dos Santos G, Fargo DC, Xie B, Gao Y, Li L, Adelman K.
Cell
View full abstract on Pubmed
Probing TBP interactions in transcription initiation and reinitiation with RNA aptamers that act in distinct modes.
Authors: Authors: Fan X, Shi H, Adelman K, Lis JT.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
NF-Y controls fidelity of transcription initiation at gene promoters through maintenance of the nucleosome-depleted region.
Authors: Authors: Oldfield AJ, Henriques T, Kumar D, Burkholder AB, Cinghu S, Paulet D, Bennett BD, Yang P, Scruggs BS, Lavender CA, Rivals E, Adelman K, Jothi R.
Nat Commun
View full abstract on Pubmed
Bidirectional Transcription Arises from Two Distinct Hubs of Transcription Factor Binding and Active Chromatin.
Authors: Authors: Scruggs BS, Gilchrist DA, Nechaev S, Muse GW, Burkholder A, Fargo DC, Adelman K.
Mol Cell
View full abstract on Pubmed
CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1.
Authors: Authors: Bartkowiak B, Liu P, Phatnani HP, Fuda NJ, Cooper JJ, Price DH, Adelman K, Lis JT, Greenleaf AL.
Genes Dev
View full abstract on Pubmed
Characterization of the interactions between the bacteriophage T4 AsiA protein and RNA polymerase.
Authors: Authors: Simeonov MF, Bieber Urbauer RJ, Gilmore JM, Adelman K, Brody EN, Niedziela-Majka A, Minakhin L, Heyduk T, Urbauer JL.
Biochemistry
View full abstract on Pubmed
PCIF1 Catalyzes m6Am mRNA Methylation to Regulate Gene Expression.
Authors: Authors: Sendinc E, Valle-Garcia D, Dhall A, Chen H, Henriques T, Navarrete-Perea J, Sheng W, Gygi SP, Adelman K, Shi Y.
Mol Cell
View full abstract on Pubmed
Pausing of RNA polymerase II regulates mammalian developmental potential through control of signaling networks.
Authors: Authors: Williams LH, Fromm G, Gokey NG, Henriques T, Muse GW, Burkholder A, Fargo DC, Hu G, Adelman K.
Mol Cell
View full abstract on Pubmed