Lauren Orefice, PhD

Assistant Professor of Genetics, Massachusetts General Hospital
Outside-in: Rethinking the etiology of autism spectrum disorders
Authors: Authors: Orefice LL.
Science
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Targeting Peripheral Somatosensory Neurons to Improve Tactile-Related Phenotypes in ASD Models.
Authors: Authors: Orefice LL, Mosko JR, Morency DT, Wells MF, Tasnim A, Mozeika SM, Ye M, Chirila AM, Emanuel AJ, Rankin G, Fame RM, Lehtinen MK, Feng G, Ginty DD.
Cell
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Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis.
Authors: Authors: Ast T, Meisel JD, Patra S, Wang H, Grange RMH, Kim SH, Calvo SE, Orefice LL, Nagashima F, Ichinose F, Zapol WM, Ruvkun G, Barondeau DP, Mootha VK.
Cell
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Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice.
Authors: Authors: Chen CM, Orefice LL, Chiu SL, LeGates TA, Hattar S, Huganir RL, Zhao H, Xu B, Kuruvilla R.
Proc Natl Acad Sci U S A
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The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn.
Authors: Authors: Abraira VE, Kuehn ED, Chirila AM, Springel MW, Toliver AA, Zimmerman AL, Orefice LL, Boyle KA, Bai L, Song BJ, Bashista KA, O'Neill TG, Zhuo J, Tsan C, Hoynoski J, Rutlin M, Kus L, Niederkofler V, Watanabe M, Dymecki SM, Nelson SB, Heintz N, Hughes DI, Ginty DD.
Cell
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Peripheral Mechanosensory Neuron Dysfunction Underlies Tactile and Behavioral Deficits in Mouse Models of ASDs.
Authors: Authors: Orefice LL, Zimmerman AL, Chirila AM, Sleboda SJ, Head JP, Ginty DD.
Cell
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Control of spine maturation and pruning through proBDNF synthesized and released in dendrites.
Authors: Authors: Orefice LL, Shih CC, Xu H, Waterhouse EG, Xu B.
Mol Cell Neurosci
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Distinct roles for somatically and dendritically synthesized brain-derived neurotrophic factor in morphogenesis of dendritic spines.
Authors: Authors: Orefice LL, Waterhouse EG, Partridge JG, Lalchandani RR, Vicini S, Xu B.
J Neurosci
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BDNF promotes differentiation and maturation of adult-born neurons through GABAergic transmission.
Authors: Authors: Waterhouse EG, An JJ, Orefice LL, Baydyuk M, Liao GY, Zheng K, Lu B, Xu B.
J Neurosci
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Paternal care paradoxically increases offspring seizure susceptibility in the El mouse model of epilepsy.
Authors: Authors: Orefice LL, Heinrichs SC.
Epilepsy Behav
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