Tim Mitchison

Timothy Mitchison, PhD

Hasib Sabbagh Professor of Systems Biology, Harvard Medical School

Tim Mitchison, PhD, received his BA in Biochemistry from Oxford University, England, in 1980, and his PhD from the University of California, San Francisco (UCSF), in Biochemistry and Biophysics in 1984, where he worked with Professor Marc Kirschner. At this time he discovered the dynamic instability of microtubules. Later he worked at the National Institute for Medical Research in London. In 1987 he returned to San Francisco to become an Assistant Professor at UCSF. In 1997 he moved to the Cell Biology Department at Harvard Medical School where he co-founded the Institute for Chemistry and Cell Biology.

Dr. Mitchison was a founding member of the HMS Department of Systems Biology, which started in 2004. He is currently Deputy Chair of the department, and Co-director of the Systems Biology PhD Program. He was elected a Fellow of the Royal Society in 1997, and member of the American Association of Arts and Sciences in 2008. In 2010 he served as President of the American Society of Cell Biology. And most recently in 2014 he became a member of the National Academy of Sciences.

Unsupervised identification of disease states from high-dimensional physiological and histopathological profiles.
Authors: Authors: Shimada K, Mitchison TJ.
Mol Syst Biol
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IRF3 and type I interferons fuel a fatal response to myocardial infarction.
Authors: Authors: King KR, Aguirre AD, Ye YX, Sun Y, Roh JD, Ng RP, Kohler RH, Arlauckas SP, Iwamoto Y, Savol A, Sadreyev RI, Kelly M, Fitzgibbons TP, Fitzgerald KA, Mitchison T, Libby P, Nahrendorf M, Weissleder R.
Nat Med
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Anti-Microtubule Drugs.
Authors: Authors: Florian S, Mitchison TJ.
Methods Mol Biol
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Quantitative analysis of resistance to natural killer attacks reveals stepwise killing kinetics.
Authors: Authors: Choi PJ, Mitchison TJ.
Integr Biol (Camb)
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Self-organization of stabilized microtubules by both spindle and midzone mechanisms in Xenopus egg cytosol.
Authors: Authors: Mitchison TJ, Nguyen P, Coughlin M, Groen AC.
Mol Biol Cell
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Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction.
Authors: Authors: Orth JD, Loewer A, Lahav G, Mitchison TJ.
Mol Biol Cell
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Cell death when the SAC is out of commission.
Authors: Authors: Huang HC, Shi J, Orth JD, Mitchison TJ.
Cell Cycle
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A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish.
Authors: Authors: Niethammer P, Grabher C, Look AT, Mitchison TJ.
Nature
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Implications of a poroelastic cytoplasm for the dynamics of animal cell shape.
Authors: Authors: Mitchison TJ, Charras GT, Mahadevan L.
Semin Cell Dev Biol
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NuSAP, a mitotic RanGTP target that stabilizes and cross-links microtubules.
Authors: Authors: Ribbeck K, Groen AC, Santarella R, Bohnsack MT, Raemaekers T, Köcher T, Gentzel M, Görlich D, Wilm M, Carmeliet G, Mitchison TJ, Ellenberg J, Hoenger A, Mattaj IW.
Mol Biol Cell
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