Assessment of targeted protein degradation as a strategy for potent antivirals with high barriers to resistance

Developing novel therapeutic approaches for CNS drug delivery by targeting a newly identified key regulator of the blood brain barrier

Development of a new precision therapeutic for an important cancer target

Development of AAV-mediated mini-gene therapy for Usher syndrome type 1F, a combined deafness and blindness

Development of an inexpensive at-home influenza kit and detection technology

Development of small molecule modulators of autophagy and ER stress as novel therapeutics for AD

Development of synthetic analogs of a sleeve gastrectomy-induced metabolite as a novel therapy for type 2 diabetes and obesity

Isoguvacine and benzodiazepine derivatives for the treatment of tactile hypersensitivity and anxiety in autism spectrum disorders

Microtubule stabilizing drugs for neurodegenerative disease and spinal cord injury

Small molecule modulators of bile acid metabolism to treat NAFLD/NASH

Small molecule modulators of gut bacterial bile acid metabolism to treat metabolic syndrome and associated non-alcoholic fatty liver disease (NAFLD)