We are developing a treatment for pancreatitis based on a protease inhibitor with enhanced pharmacokinetics and tissue distribution. Initial experiments indicate that an engineered protein lead compound can be inexpensively produced at high levels, is active in vitro, and is active in initial animal tests.

Funding

Funding Duration

July 1, 2019 - June 30, 2021

Funding level

Development

People

Principal Investigator

Pamela Silver

PhD
Elliott T. and Onie H. Adams Professor of Biochemistry and Systems Biology, Harvard Medical School
Co-PI

Daniel Heid

BSc
MSc candidate Molecular Biotechnology, Heidelberg University

Jungmin Lee

PhD
Postdoctoral Fellow, Harvard Medical School

Dominik Niopek

PhD
Group Leader, Heidelberg University, Institute for Pharmacy and Molecular Biotechnology

Jeffrey Way

PhD
Senior Staff Scientist - Synthetic and Structural Biology, Harvard University

Intellectual Property

Patents

WO2022235551
:
Protein drugs for pancreatitis
(Provisional patent application)

Follow on Funding and Exits

Internal Funding