Wade Harper

Wade Harper

Member
Harper

Wade Harper is the Bert and Natalie Vallee Professor of Molecular Pathology and the Chairman of the Department of Cell Biology at Harvard Medical School, and is also the Co-Director of the Dana Farber/Harvard Cancer Center Program in Cancer Cell Biology. Dr. Harper received a PhD from Georgia Institute of Technology in chemistry and was a post-doctoral fellow at Harvard Medical School prior to starting his independent faculty position at Baylor College of Medicine in the Department of Biochemistry.  Dr. Harper was recruited to HMS in 2003. Dr. Harper’s work focuses on the analysis of molecular circuits regulating cellular decisions, including regulated protein turnover by the ubiquitin and autophagy systems, and the architecture of the human interactome. Early work from his lab focused on the functions, mechanisms and targets of two major regulatory systems involved in cell cycle control and DNA repair – cyclin-dependent kinases and the cullin-RING ubiquitin ligase system. Recent work from his lab has led to the discovery of a phosphorylation-driven feed-forward ubiquitylation pathway controlling PARKIN-dependent mitophagy, and a molecular understanding of the pathways controlling selective autophagy. In addition, Dr. Harper has employed interaction proteomics to define interactions and complexes for more than 10,000 human proteins, providing numerous complexes linked to biological pathways and disease. Awards include a Vallee Visiting Professorship, the Javits Neuroscience award from the National Institutes of Health, and election to the American Society of Arts and Sciences.