Amy Wagers

Amy Wagers, PhD

Forst Family Professor of Stem Cell and Regenerative Biology, Faculty of Arts & Sciences, Harvard University

Dr. Amy Wagers is a Harvard College Professor and the Forst Family Professor and Co-Chair of the Department of Stem Cell and Regenerative Biology at Harvard University. She is also a Principal Faculty member of the Harvard Stem Cell Institute, a Senior Investigator in the Section on Islet Cell and Regenerative Biology at the Joslin Diabetes Center and a member of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School.  Dr. Wagers’ laboratory investigates how changes in stem cell activity impact tissue homeostasis and repair throughout life, and how stem cells may be harnessed for regenerative medicine using cell transplantation and gene editing approaches.

Rejuvenation of aged progenitor cells by exposure to a young systemic environment.
Authors: Authors: Conboy IM, Conboy MJ, Wagers AJ, Girma ER, Weissman IL, Rando TA.
Nature
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Little evidence for developmental plasticity of adult hematopoietic stem cells.
Authors: Authors: Wagers AJ, Sherwood RI, Christensen JL, Weissman IL.
Science
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An sLex-deficient variant of HL60 Cells exhibits high levels of adhesion to vascular selectins: further evidence that HECA-452 and CSLEX1 monoclonal antibody epitopes are not essential for high avidity binding to vascular selectins
Authors: Authors: Wagers AJ, Stoolman LM, Craig R, Knibbs RN, Kansas GS
Journal of Immunology
Variation in zygotic CRISPR/Cas9 gene editing outcomes generates novel reporter and deletion alleles at the Gdf11 locus.
Authors: Authors: Goldstein JM, Valido A, Lewandowski JP, Walker RG, Mills MJ, Messemer KA, Besseling P, Lee KH, Wattrus SJ, Cho M, Lee RT, Wagers AJ.
Sci Rep
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Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification.
Authors: Authors: Dey D, Bagarova J, Hatsell SJ, Armstrong KA, Huang L, Ermann J, Vonner AJ, Shen Y, Mohedas AH, Lee A, Eekhoff EM, van Schie A, Demay MB, Keller C, Wagers AJ, Economides AN, Yu PB.
Sci Transl Med
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Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma.
Authors: Authors: Hettmer S, Schinzel AC, Tchessalova D, Schneider M, Parker CL, Bronson RT, Richards NG, Hahn WC, Wagers AJ.
Elife
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How stem cells get "turned on".
Authors: Authors: Wagers AJ.
EMBO J
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A special population of regulatory T cells potentiates muscle repair.
Authors: Authors: Burzyn D, Kuswanto W, Kolodin D, Shadrach JL, Cerletti M, Jang Y, Sefik E, Tan TG, Wagers AJ, Benoist C, Mathis D.
Cell
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Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells.
Authors: Authors: Cohen NR, Brennan PJ, Shay T, Watts GF, Brigl M, Kang J, Brenner MB.
Nat Immunol
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Early life nutrition modulates muscle stem cell number: implications for muscle mass and repair.
Authors: Authors: Woo M, Isganaitis E, Cerletti M, Fitzpatrick C, Wagers AJ, Jimenez-Chillaron J, Patti ME.
Stem Cells Dev
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