Amy Wagers

Amy Wagers, PhD

Forst Family Professor of Stem Cell and Regenerative Biology, Faculty of Arts & Sciences, Harvard University

Dr. Amy Wagers is a Harvard College Professor and the Forst Family Professor and Co-Chair of the Department of Stem Cell and Regenerative Biology at Harvard University. She is also a Principal Faculty member of the Harvard Stem Cell Institute, a Senior Investigator in the Section on Islet Cell and Regenerative Biology at the Joslin Diabetes Center and a member of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School.  Dr. Wagers’ laboratory investigates how changes in stem cell activity impact tissue homeostasis and repair throughout life, and how stem cells may be harnessed for regenerative medicine using cell transplantation and gene editing approaches.

A multifunctional AAV-CRISPR-Cas9 and its host response.
Authors: Authors: Chew WL, Tabebordbar M, Cheng JK, Mali P, Wu EY, Ng AH, Zhu K, Wagers AJ, Church GM.
Nat Methods
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Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells.
Authors: Authors: Kowalczyk MS, Tirosh I, Heckl D, Rao TN, Dixit A, Haas BJ, Schneider RK, Wagers AJ, Ebert BL, Regev A.
Genome Res
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Stem cell aging: mechanisms, regulators and therapeutic opportunities.
Authors: Authors: Oh J, Lee YD, Wagers AJ.
Nat Med
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Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction.
Authors: Authors: Zangi L, Lui KO, von Gise A, Ma Q, Ebina W, Ptaszek LM, Später D, Xu H, Tabebordbar M, Gorbatov R, Sena B, Nahrendorf M, Briscoe DM, Li RA, Wagers AJ, Rossi DJ, Pu WT, Chien KR.
Nat Biotechnol
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A cell-autonomous defect in skeletal muscle satellite cells expressing low levels of survival of motor neuron protein.
Authors: Authors: Hayhurst M, Wagner AK, Cerletti M, Wagers AJ, Rubin LL.
Dev Biol
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Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells.
Authors: Authors: Polo JM, Liu S, Figueroa ME, Kulalert W, Eminli S, Tan KY, Apostolou E, Stadtfeld M, Li Y, Shioda T, Natesan S, Wagers AJ, Melnick A, Evans T, Hochedlinger K.
Nat Biotechnol
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Highly efficient, functional engraftment of skeletal muscle stem cells in dystrophic muscles.
Authors: Authors: Cerletti M, Jurga S, Witczak CA, Hirshman MF, Shadrach JL, Goodyear LJ, Wagers AJ.
Cell
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Ovulated oocytes in adult mice derive from non-circulating germ cells.
Authors: Authors: Eggan K, Jurga S, Gosden R, Min IM, Wagers AJ.
Nature
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Incorporation of naive bone marrow derived cells into the vascular architecture of brain tumor.
Authors: Authors: Yung YC, Cheshier S, Santarelli JG, Huang Z, Wagers A, Weissman I, Tse V.
Microcirculation
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Changes in integrin expression are associated with altered homing properties of hematopoietic stem cells following mobilization by cyclophosphamide/ granulocyte colony-stimulating factor
Authors: Authors: Wagers AJ, Allsopp RA, Weissman, IL
Experimantal Hematology