Artur Indzhykulian, PhD

Assistant Professor of Otolaryngology Head and Neck Surgery, Massachusetts Eye and Ear Infirmary
PKHD1L1 is a coat protein of hair-cell stereocilia and is required for normal hearing.
Authors: Authors: Wu X, Ivanchenko MV, Al Jandal H, Cicconet M, Indzhykulian AA, Corey DP.
Nat Commun
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Gene Transfer with AAV9-PHP.B Rescues Hearing in a Mouse Model of Usher Syndrome 3A and Transduces Hair Cells in a Non-human Primate.
Authors: Authors: György B, Meijer EJ, Ivanchenko MV, Tenneson K, Emond F, Hanlon KS, Indzhykulian AA, Volak A, Karavitaki KD, Tamvakologos PI, Vezina M, Berezovskii VK, Born RT, O'Brien M, Lafond JF, Arsenijevic Y, Kenna MA, Maguire CA, Corey DP.
Mol Ther Methods Clin Dev
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Mechanotransduction current is essential for stability of the transducing stereocilia in mammalian auditory hair cells.
Authors: Authors: Vélez-Ortega AC, Freeman MJ, Indzhykulian AA, Grossheim JM, Frolenkov GI.
Elife
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Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c.
Authors: Authors: Pan B, Askew C, Galvin A, Heman-Ackah S, Asai Y, Indzhykulian AA, Jodelka FM, Hastings ML, Lentz JJ, Vandenberghe LH, Holt JR, Géléoc GS.
Nat Biotechnol
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Rescue of Hearing by Gene Delivery to Inner-Ear Hair Cells Using Exosome-Associated AAV.
Authors: Authors: György B, Sage C, Indzhykulian AA, Scheffer DI, Brisson AR, Tan S, Wu X, Volak A, Mu D, Tamvakologos PI, Li Y, Fitzpatrick Z, Ericsson M, Breakefield XO, Corey DP, Maguire CA.
Mol Ther
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Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing.
Authors: Authors: Vogl C, Panou I, Yamanbaeva G, Wichmann C, Mangosing SJ, Vilardi F, Indzhykulian AA, Pangršic T, Santarelli R, Rodriguez-Ballesteros M, Weber T, Jung S, Cardenas E, Wu X, Wojcik SM, Kwan KY, Del Castillo I, Schwappach B, Strenzke N, Corey DP, Lin SY, Moser T.
EMBO J
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Hair-Cell Mechanotransduction Persists in TRP Channel Knockout Mice.
Authors: Authors: Wu X, Indzhykulian AA, Niksch PD, Webber RM, Garcia-Gonzalez M, Watnick T, Zhou J, Vollrath MA, Corey DP.
PLoS One
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Primary cilia are not calcium-responsive mechanosensors.
Authors: Authors: Delling M, Indzhykulian AA, Liu X, Li Y, Xie T, Corey DP, Clapham DE.
Nature
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In the Right Place at the Right Time: Is TMC1/2 the Transduction Channel for Hearing?
Authors: Authors: Indzhykulian AA, Corey DP.
Cell Rep
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The 133-kDa N-terminal domain enables myosin 15 to maintain mechanotransducing stereocilia and is essential for hearing.
Authors: Authors: Fang Q, Indzhykulian AA, Mustapha M, Riordan GP, Dolan DF, Friedman TB, Belyantseva IA, Frolenkov GI, Camper SA, Bird JE.
Elife
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