Clifford Woolf, PhD, MB, BCh
Professor of Neurology, Boston Children's Hospital
Bupivacaine-induced cellular entry of QX-314 and its contribution to differential nerve block.
Authors: Authors: Brenneis C, Kistner K, Puopolo M, Jo S, Roberson D, Sisignano M, Segal D, Cobos EJ, Wainger BJ, Labocha S, Ferreirós N, von Hehn C, Tran J, Geisslinger G, Reeh PW, Bean BP, Woolf CJ.
Br J Pharmacol
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Br J Pharmacol
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Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity.
Authors: Authors: Sorge RE, Trang T, Dorfman R, Smith SB, Beggs S, Ritchie J, Austin JS, Zaykin DV, Vander Meulen H, Costigan M, Herbert TA, Yarkoni-Abitbul M, Tichauer D, Livneh J, Gershon E, Zheng M, Tan K, John SL, Slade GD, Jordan J, Woolf CJ, Peltz G, Maixner W, Diatchenko L, Seltzer Z, Salter MW, Mogil JS.
Nat Med
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Nat Med
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Overcoming obstacles to developing new analgesics.
Nociceptors are interleukin-1beta sensors.
Authors: Authors: Binshtok AM, Wang H, Zimmermann K, Amaya F, Vardeh D, Shi L, Brenner GJ, Ji RR, Bean BP, Woolf CJ, Samad TA.
J Neurosci
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J Neurosci
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Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors.
Authors: Authors: Agarwal N, Pacher P, Tegeder I, Amaya F, Constantin CE, Brenner GJ, Rubino T, Michalski CW, Marsicano G, Monory K, Mackie K, Marian C, Batkai S, Parolaro D, Fischer MJ, Reeh P, Kunos G, Kress M, Lutz B, Woolf CJ, Kuner R.
Nat Neurosci
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Nat Neurosci
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Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy.
Authors: Authors: McCampbell A, Truong D, Broom DC, Allchorne A, Gable K, Cutler RG, Mattson MP, Woolf CJ, Frosch MP, Harmon JM, Dunn TM, Brown RH.
Hum Mol Genet
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Hum Mol Genet
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Axonal injury-dependent induction of the peripheral benzodiazepine receptor in small-diameter adult rat primary sensory neurons.
Authors: Authors: Karchewski LA, Bloechlinger S, Woolf CJ.
Eur J Neurosci
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Eur J Neurosci
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A conditional deletion of the NR1 subunit of the NMDA receptor in adult spinal cord dorsal horn reduces NMDA currents and injury-induced pain.
Authors: Authors: South SM, Kohno T, Kaspar BK, Hegarty D, Vissel B, Drake CT, Ohata M, Jenab S, Sailer AW, Malkmus S, Masuyama T, Horner P, Bogulavsky J, Gage FH, Yaksh TL, Woolf CJ, Heinemann SF, Inturrisi CE.
J Neurosci
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J Neurosci
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The pattern of expression of the voltage-gated sodium channels Na(v)1.8 and Na(v)1.9 does not change in uninjured primary sensory neurons in experimental neuropathic pain models.
Turbocharging neurons for growth: accelerating regeneration in the adult CNS.