David Golan

David Golan, MD, PhD

Dean for Research Operations and Global Programs, Harvard Medical School
George R. Minot Professor of Medicine, Harvard Medical School
Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School

David E. Golan, the George R. Minot Professor of Medicine and Professor of Biological Chemistry and Molecular Pharmacology at HMS, was appointed dean for research operations and global programs in 2019. He previously served for 11 years as HMS dean for basic science and graduate education and special advisor for global programs. His laboratory in the Department of Biological Chemistry and Molecular Pharmacology applies biophysical and cell-imaging methods to the study of membrane proteins in blood cells. Dr. Golan is a senior physician in the Department of Medicine at Brigham and Women’s Hospital and Dana-Farber Cancer Institute, where he sees patients as a practicing hematologist and clinician teacher. Dr. Golan founded and directed the core course in pharmacology in the New Pathway curriculum at HMS from 1989 to 2006, and he co-directs a translational pharmacology course that brings together PhD students in the Therapeutics Graduate Program with MD fellows in the Master of Medical Sciences Program in Clinical Investigation at HMS. He also co-directs the Harvard Therapeutics Graduate Program and is editor-in-chief of Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, an award-winning textbook of pharmacology that is used worldwide. In his role as dean for research operations and global programs, Dr. Golan is responsible for planning, coordination and operations involving research in the School’s basic and social science departments and for planning, implementation and oversight of interdisciplinary, interdepartmental, School-wide, inter-institutional and global research initiatives and technology platforms at HMS.

Endothelial cell cortactin coordinates intercellular adhesion molecule-1 clustering and actin cytoskeleton remodeling during polymorphonuclear leukocyte adhesion and transmigration.
Authors: Authors: Yang L, Kowalski JR, Yacono P, Bajmoczi M, Shaw SK, Froio RM, Golan DE, Thomas SM, Luscinskas FW.
J Immunol
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Single-particle tracking and laser optical tweezers studies of the dynamics of individual protein molecules in membranes of intact human and mouse red cells.
Authors: Authors: Mirchev R, Golan DE.
Blood Cells Mol Dis
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Statistical modeling of coverage in high-throughput data.
Authors: Authors: Golan D, Rosset S.
Methods Mol Biol
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Cystic fibrosis transmembrane conductance regulator and caveolin-1 regulate epithelial cell internalization of Pseudomonas aeruginosa.
Authors: Authors: Bajmoczi M, Gadjeva M, Alper SL, Pier GB, Golan DE.
Am J Physiol Cell Physiol
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Cytoskeletal regulation couples LFA-1 conformational changes to receptor lateral mobility and clustering.
Authors: Authors: Cairo CW, Mirchev R, Golan DE.
Immunity
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Dynamic shuttling of TIA-1 accompanies the recruitment of mRNA to mammalian stress granules.
Authors: Authors: Kedersha N, Cho MR, Li W, Yacono PW, Chen S, Gilks N, Golan DE, Anderson P.
J Cell Biol
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Membrane protein dynamics and functional implications in mammalian cells.
Authors: Authors: Alenghat FJ, Golan DE.
Curr Top Membr
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C3b deposition on human erythrocytes induces the formation of a membrane skeleton-linked protein complex.
Authors: Authors: Karnchanaphanurach P, Mirchev R, Ghiran I, Asara JM, Papahadjopoulos-Sternberg B, Nicholson-Weller A, Golan DE.
J Clin Invest
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Site-specific protein labeling by Sfp phosphopantetheinyl transferase.
Authors: Authors: Yin J, Lin AJ, Golan DE, Walsh CT.
Nat Protoc
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Breast-fed and formula-fed infants do not differ in immunocompetent cell cytokine production despite differences in cell membrane fatty acid composition.
Authors: Authors: Granot E, Golan D, Berry EM.
Am J Clin Nutr
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