David Golan

David Golan, MD, PhD

Dean for Research Operations and Global Programs, Harvard Medical School
George R. Minot Professor of Medicine, Harvard Medical School
Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School

David E. Golan, the George R. Minot Professor of Medicine and Professor of Biological Chemistry and Molecular Pharmacology at HMS, was appointed dean for research operations and global programs in 2019. He previously served for 11 years as HMS dean for basic science and graduate education and special advisor for global programs. His laboratory in the Department of Biological Chemistry and Molecular Pharmacology applies biophysical and cell-imaging methods to the study of membrane proteins in blood cells. Dr. Golan is a senior physician in the Department of Medicine at Brigham and Women’s Hospital and Dana-Farber Cancer Institute, where he sees patients as a practicing hematologist and clinician teacher. Dr. Golan founded and directed the core course in pharmacology in the New Pathway curriculum at HMS from 1989 to 2006, and he co-directs a translational pharmacology course that brings together PhD students in the Therapeutics Graduate Program with MD fellows in the Master of Medical Sciences Program in Clinical Investigation at HMS. He also co-directs the Harvard Therapeutics Graduate Program and is editor-in-chief of Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, an award-winning textbook of pharmacology that is used worldwide. In his role as dean for research operations and global programs, Dr. Golan is responsible for planning, coordination and operations involving research in the School’s basic and social science departments and for planning, implementation and oversight of interdisciplinary, interdepartmental, School-wide, inter-institutional and global research initiatives and technology platforms at HMS.

Protein therapeutics: a summary and pharmacological classification.
Authors: Authors: Leader B, Baca QJ, Golan DE.
Nat Rev Drug Discov
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Small interfering RNA-mediated down-regulation of caveolin-1 differentially modulates signaling pathways in endothelial cells.
Authors: Authors: Gonzalez E, Nagiel A, Lin AJ, Golan DE, Michel T.
J Biol Chem
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NF2/Merlin mediates contact-dependent inhibition of EGFR mobility and internalization via cortical actomyosin.
Authors: Authors: Chiasson-MacKenzie C, Morris ZS, Baca Q, Morris B, Coker JK, Mirchev R, Jensen AE, Carey T, Stott SL, Golan DE, McClatchey AI.
J Cell Biol
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Feed-forward microprocessing and splicing activities at a microRNA-containing intron.
Authors: Authors: Janas MM, Khaled M, Schubert S, Bernstein JG, Golan D, Veguilla RA, Fisher DE, Shomron N, Levy C, Novina CD.
PLoS Genet
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Atrial natriuretic peptide-initiated cGMP pathways regulate vasodilator-stimulated phosphoprotein phosphorylation and angiogenesis in vascular endothelium.
Authors: Authors: Chen H, Levine YC, Golan DE, Michel T, Lin AJ.
J Biol Chem
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Chemical genetics to identify NFAT inhibitors: potential of targeting calcium mobilization in immunosuppression.
Authors: Authors: Venkatesh N, Feng Y, DeDecker B, Yacono P, Golan D, Mitchison T, McKeon F.
Proc Natl Acad Sci U S A
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Reply to Lee: Downward bias in heritability estimation is not due to simplified linkage equilibrium SNP simulation.
Authors: Authors: Golan D, Rosset S, Lander ES.
Proc Natl Acad Sci U S A
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Membrane compartmentalization in Southeast Asian ovalocytosis red blood cells.
Authors: Authors: Mirchev R, Lam A, Golan DE.
Br J Haematol
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Host resistance to lung infection mediated by major vault protein in epithelial cells.
Authors: Authors: Kowalski MP, Dubouix-Bourandy A, Bajmoczi M, Golan DE, Zaidi T, Coutinho-Sledge YS, Gygi MP, Gygi SP, Wiemer EA, Pier GB.
Science
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Subdivision of essential tremor patients according to physiologic characteristics.
Authors: Authors: Golan D, Giladi N, Thorne R, Korczyn AD, Simon ES.
Acta Neurol Scand
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