David Golan

David Golan, MD, PhD

Dean for Research Operations and Global Programs, Harvard Medical School
George R. Minot Professor of Medicine, Harvard Medical School
Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School

David E. Golan, the George R. Minot Professor of Medicine and Professor of Biological Chemistry and Molecular Pharmacology at HMS, was appointed dean for research operations and global programs in 2019. He previously served for 11 years as HMS dean for basic science and graduate education and special advisor for global programs. His laboratory in the Department of Biological Chemistry and Molecular Pharmacology applies biophysical and cell-imaging methods to the study of membrane proteins in blood cells. Dr. Golan is a senior physician in the Department of Medicine at Brigham and Women’s Hospital and Dana-Farber Cancer Institute, where he sees patients as a practicing hematologist and clinician teacher. Dr. Golan founded and directed the core course in pharmacology in the New Pathway curriculum at HMS from 1989 to 2006, and he co-directs a translational pharmacology course that brings together PhD students in the Therapeutics Graduate Program with MD fellows in the Master of Medical Sciences Program in Clinical Investigation at HMS. He also co-directs the Harvard Therapeutics Graduate Program and is editor-in-chief of Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, an award-winning textbook of pharmacology that is used worldwide. In his role as dean for research operations and global programs, Dr. Golan is responsible for planning, coordination and operations involving research in the School’s basic and social science departments and for planning, implementation and oversight of interdisciplinary, interdepartmental, School-wide, inter-institutional and global research initiatives and technology platforms at HMS.

Genetically encoded short peptide tags for orthogonal protein labeling by Sfp and AcpS phosphopantetheinyl transferases.
Authors: Authors: Zhou Z, Cironi P, Lin AJ, Xu Y, Hrvatin S, Golan DE, Silver PA, Walsh CT, Yin J.
ACS Chem Biol
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Receptor-regulated dynamic interaction between endothelial nitric oxide synthase and calmodulin revealed by fluorescence resonance energy transfer in living cells.
Authors: Authors: Jobin CM, Chen H, Lin AJ, Yacono PW, Igarashi J, Michel T, Golan DE.
Biochemistry
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Measuring missing heritability: inferring the contribution of common variants.
Authors: Authors: Golan D, Lander ES, Rosset S.
Proc Natl Acad Sci U S A
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Analysis of molecular diffusion by first-passage time variance identifies the size of confinement zones.
Authors: Authors: Rajani V, Carrero G, Golan DE, de Vries G, Cairo CW.
Biophys J
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Adherent leukocytes capture sickle erythrocytes in an in vitro flow model of vaso-occlusion.
Authors: Authors: Finnegan EM, Turhan A, Golan DE, Barabino GA.
Am J Hematol
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Critical role of mitochondrial damage in determining outcome of macrophage infection with Mycobacterium tuberculosis.
Authors: Authors: Duan L, Gan H, Golan DE, Remold HG.
J Immunol
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Effective genetic-risk prediction using mixed models.
Authors: Authors: Golan D, Rosset S.
Am J Hum Genet
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Ligation of complement receptor 1 increases erythrocyte membrane deformability.
Authors: Authors: Glodek AM, Mirchev R, Golan DE, Khoory JA, Burns JM, Shevkoplyas SS, Nicholson-Weller A, Ghiran IC.
Blood
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Resistance to Pseudomonas aeruginosa chronic lung infection requires cystic fibrosis transmembrane conductance regulator-modulated interleukin-1 (IL-1) release and signaling through the IL-1 receptor.
Authors: Authors: Reiniger N, Lee MM, Coleman FT, Ray C, Golan DE, Pier GB.
Infect Immun
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Subcellular targeting and agonist-induced site-specific phosphorylation of endothelial nitric-oxide synthase.
Authors: Authors: Gonzalez E, Kou R, Lin AJ, Golan DE, Michel T.
J Biol Chem
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