David Knipe, PhD
Higgins Professor of Microbiology and Molecular Genetics, Harvard Medical School
ATRX promotes maintenance of herpes simplex virus heterochromatin during chromatin stress.
Herpesviral ICP0 Protein Promotes Two Waves of Heterochromatin Removal on an Early Viral Promoter during Lytic Infection.
Identification of TRIM27 as a novel degradation target of herpes simplex virus 1 ICP0.
Identification of a divalent metal cation binding site in herpes simplex virus 1 (HSV-1) ICP8 required for HSV replication.
Herpes simplex virus-1 infection causes the secretion of a type I interferon-antagonizing protein and inhibits signaling at or before Jak-1 activation.
Inhibitors of the sodium potassium ATPase that impair herpes simplex virus replication identified via a chemical screening approach.
Evidence for a direct interaction between HSV-1 ICP27 and ICP8 proteins.
Authors: Authors: Olesky M, McNamee EE, Zhou C, Taylor TJ, Knipe DM.
Virology
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Virology
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Herpes simplex virus replication compartments can form by coalescence of smaller compartments.
Herpes simplex virus-induced keratitis: evaluation of the role of molecular mimicry in lesion pathogenesis.
Authors: Authors: Deshpande SP, Lee S, Zheng M, Song B, Knipe D, Kapp JA, Rouse BT.
J Virol
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J Virol
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Contributions of antibody and T cell subsets to protection elicited by immunization with a replication-defective mutant of herpes simplex virus type 1.