David Knipe, PhD

Higgins Professor of Microbiology and Molecular Genetics, Harvard Medical School
A deletion mutant of the latency-associated transcript of herpes simplex virus type 1 reactivates from the latent state with reduced frequency.
Authors: Authors: Leib DA, Bogard CL, Kosz-Vnenchak M, Hicks KA, Coen DM, Knipe DM, Schaffer PA.
J Virol
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Identification of a herpes simplex virus function that represses late gene expression from parental viral genomes.
Authors: Authors: Godowski PJ, Knipe DM.
J Virol
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Molecular genetics of herpes simplex virus. VII. Characterization of a temperature-sensitive mutant produced by in vitro mutagenesis and defective in DNA synthesis and accumulation of gamma polypeptides.
Authors: Authors: Conley AJ, Knipe DM, Jones PC, Roizman B.
J Virol
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Translation of individual species of vesicular stomatitis viral mRNA.
Authors: Authors: Knipe D, Rose JK, Lodish HF.
J Virol
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Generation of an Oncolytic Herpes Simplex Virus 1 Expressing Human MelanA.
Authors: Authors: Boscheinen JB, Thomann S, Knipe DM, DeLuca N, Schuler-Thurner B, Gross S, Dörrie J, Schaft N, Bach C, Rohrhofer A, Werner-Klein M, Schmidt B, Schuster P.
Front Immunol
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HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression.
Authors: Authors: Christensen MH, Jensen SB, Miettinen JJ, Luecke S, Prabakaran T, Reinert LS, Mettenleiter T, Chen ZJ, Knipe DM, Sandri-Goldin RM, Enquist LW, Hartmann R, Mogensen TH, Rice SA, Nyman TA, Matikainen S, Paludan SR.
EMBO J
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HSV-1 remodels host telomeres to facilitate viral replication.
Authors: Authors: Deng Z, Kim ET, Vladimirova O, Dheekollu J, Wang Z, Newhart A, Liu D, Myers JL, Hensley SE, Moffat J, Janicki SM, Fraser NW, Knipe DM, Weitzman MD, Lieberman PM.
Cell Rep
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Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein.
Authors: Authors: Orzalli MH, DeLuca NA, Knipe DM.
Proc Natl Acad Sci U S A
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Simian TRIM5alpha proteins reduce replication of herpes simplex virus.
Authors: Authors: Reszka N, Zhou C, Song B, Sodroski JG, Knipe DM.
Virology
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Disruption of the U(L)41 gene in the herpes simplex virus 2 dl5-29 mutant increases its immunogenicity and protective capacity in a murine model of genital herpes.
Authors: Authors: Dudek T, Mathews LC, Knipe DM.
Virology
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