David Knipe, PhD
Higgins Professor of Microbiology and Molecular Genetics, Harvard Medical School
Roles of the nuclear lamina in stable nuclear association and assembly of a herpesviral transactivator complex on viral immediate-early genes.
Authors: Authors: Silva L, Oh HS, Chang L, Yan Z, Triezenberg SJ, Knipe DM.
MBio
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MBio
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Transcription of the herpes simplex virus latency-associated transcript promotes the formation of facultative heterochromatin on lytic promoters.
Recruitment of activated IRF-3 and CBP/p300 to herpes simplex virus ICP0 nuclear foci: Potential role in blocking IFN-beta induction.
Herpes simplex virus and toll-like receptors.
Vaginal submucosal dendritic cells, but not Langerhans cells, induce protective Th1 responses to herpes simplex virus-2.
Authors: Authors: Zhao X, Deak E, Soderberg K, Linehan M, Spezzano D, Zhu J, Knipe DM, Iwasaki A.
J Exp Med
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J Exp Med
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“Virus-Host Cell Interactions” Chapter 7
Authors: Authors: Knipe DM, Samuel CE, Palese P
In: Fields Virology, Fourth Edition, D.M
In: Fields Virology, Fourth Edition, D.M
Construction and characterization of a replication-defective herpes simplex virus 2 ICP8 mutant strain and its use in immunization studies in a guinea pig model of genital disease.
Authors: Authors: Da Costa XJ, Bourne N, Stanberry LR, Knipe DM.
Virology
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Virology
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"Persistence of viruses."
Authors: Authors: Ahmed R, Morrison LA, Knipe DM
In: Virology, 3rd ed
In: Virology, 3rd ed
Distal protein sequences can affect the function of a nuclear localization signal.
Formation of DNA replication structures in herpes virus-infected cells requires a viral DNA binding protein.