Dennis Kasper, MD

William Ellery Channing Professor of Medicine, Brigham and Women's Hospital
The symbiotic bacterial surface factor polysaccharide A on Bacteroides fragilis inhibits IL-1ß-induced inflammation in human fetal enterocytes via toll receptors 2 and 4.
Authors: Authors: Jiang F, Meng D, Weng M, Zhu W, Wu W, Kasper D, Walker WA.
PLoS One
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Sphingolipids from a symbiotic microbe regulate homeostasis of host intestinal natural killer T cells.
Authors: Authors: An D, Oh SF, Olszak T, Neves JF, Avci FY, Erturk-Hasdemir D, Lu X, Zeissig S, Blumberg RS, Kasper DL.
Cell
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Microbial exposure during early life has persistent effects on natural killer T cell function.
Authors: Authors: Olszak T, An D, Zeissig S, Vera MP, Richter J, Franke A, Glickman JN, Siebert R, Baron RM, Kasper DL, Blumberg RS.
Science
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A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease.
Authors: Authors: Ochoa-Repáraz J, Mielcarz DW, Wang Y, Begum-Haque S, Dasgupta S, Kasper DL, Kasper LH.
Mucosal Immunol
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Rational chemical design of the carbohydrate in a glycoconjugate vaccine enhances IgM-to-IgG switching.
Authors: Authors: Guttormsen HK, Paoletti LC, Mansfield KG, Jachymek W, Jennings HJ, Kasper DL.
Proc Natl Acad Sci U S A
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Structural and genetic diversity of group B streptococcus capsular polysaccharides.
Authors: Authors: Cieslewicz MJ, Chaffin D, Glusman G, Kasper D, Madan A, Rodrigues S, Fahey J, Wessels MR, Rubens CE.
Infect Immun
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Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways.
Authors: Authors: Henneke P, Takeuchi O, Malley R, Lien E, Ingalls RR, Freeman MW, Mayadas T, Nizet V, Akira S, Kasper DL, Golenbock DT.
J Immunol
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Structural basis of the abscess-modulating polysaccharide A2 from Bacteroides fragilis.
Authors: Authors: Wang Y, Kalka-Moll WM, Roehrl MH, Kasper DL.
Proc Natl Acad Sci U S A
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Ozonolytic depolymerization of polysaccharides in aqueous solution.
Authors: Authors: Wang Y, Hollingsworth RI, Kasper DL.
Carbohydr Res
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Therapeutic potential of human antisera to group B streptococcal glycoconjugate vaccines in neonatal mice.
Authors: Authors: Paoletti LC, Pinel J, Rodewald AK, Kasper DL.
J Infect Dis
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