Donald Coen, PhD
Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Low-level expression and reversion both contribute to reactivation of herpes simplex virus drug-resistant mutants with mutations on homopolymeric sequences in thymidine kinase.
The herpes simplex virus processivity factor, UL42, binds DNA as a monomer.
Quantitation of rare DNAs by PCR.
Herpes simplex virus processivity factor UL42 imparts increased DNA-binding specificity to the viral DNA polymerase and decreased dissociation from primer-template without reducing the elongation rate.
Temporal regulation of herpes simplex virus type 1 UL24 mRNA expression via differential polyadenylation.
Comparative efficacy of expression of genes delivered to mouse sensory neurons with herpes virus vectors.
Authors: Authors: Davar G, Kramer MF, Garber D, Roca AL, Andersen JK, Bebrin W, Coen DM, Kosz-Vnenchak M, Knipe DM, Breakefield XO, et al.
J Comp Neurol
View full abstract on Pubmed
J Comp Neurol
View full abstract on Pubmed
A point mutation within a distinct conserved region of the herpes simplex virus DNA polymerase gene confers drug resistance.
Translational regulation of herpes simplex virus DNA polymerase.
A human cytomegalovirus mutant resistant to the nucleoside analog 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (BW B759U) induces reduced levels of BW B759U triphosphate.
Authors: Authors: Biron KK, Fyfe JA, Stanat SC, Leslie LK, Sorrell JB, Lambe CU, Coen DM.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Mutations in the herpes simplex virus DNA polymerase gene conferring hypersensitivity to aphidicolin.
Authors: Authors: Coen DM, Furman PA, Aschman DP, Schaffer PA.
Nucleic Acids Res
View full abstract on Pubmed
Nucleic Acids Res
View full abstract on Pubmed