Donald Coen, PhD
Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
The cytomegalovirus DNA polymerase subunit UL44 forms a C clamp-shaped dimer.
Authors: Authors: Appleton BA, Loregian A, Filman DJ, Coen DM, Hogle JM.
Mol Cell
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Mol Cell
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Identification, localization, and regulation of expression of the UL24 protein of herpes simplex virus type 1.
Acyclovir is phosphorylated by the human cytomegalovirus UL97 protein.
Authors: Authors: Talarico CL, Burnette TC, Miller WH, Smith SL, Davis MG, Stanat SC, Ng TI, He Z, Coen DM, Roizman B, Biron KK.
Antimicrob Agents Chemother
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Antimicrob Agents Chemother
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A viral function represses accumulation of transcripts from productive-cycle genes in mouse ganglia latently infected with herpes simplex virus.
Acyclovir-resistant, pathogenic herpesviruses.
Expanded spectrum of viral therapy in the treatment of nervous system tumors.
Authors: Authors: Markert JM, Coen DM, Malick A, Mineta T, Martuza RL.
J Neurosurg
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J Neurosurg
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A novel functional domain of an alpha-like DNA polymerase. The binding site on the herpes simplex virus polymerase for the viral UL42 protein.
Low levels of herpes simplex virus thymidine- thymidylate kinase are not limiting for sensitivity to certain antiviral drugs or for latency in a mouse model.
Generation of genetic diversity in herpes simplex virus: an antimutator phenotype maps to the DNA polymerase locus.
Authors: Authors: Hall JD, Coen DM, Fisher BL, Weisslitz M, Randall S, Almy RE, Gelep PT, Schaffer PA.
Virology
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Virology
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Mitochondrial genetics. VI. The petite mutation in Saccharomyces cerevisiae: interrelations between the loss of the p+ factor and the loss of the drug resistance mitochondrial genetic markers.
Authors: Authors: Deutsch J, Dujon B, Netter P, Petrochilo E, Slonimski PP, Bolotin-Fukuhara M, Coen D.
Genetics
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Genetics
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