Donald Coen, PhD

Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Enzymatic amplification of DNA by PCR: standard procedures and optimization.
Authors: Authors: Kramer MF, Coen DM.
Curr Protoc Cytom
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Identification of a small molecule that inhibits herpes simplex virus DNA Polymerase subunit interactions and viral replication.
Authors: Authors: Pilger BD, Cui C, Coen DM.
Chem Biol
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Neither LAT nor open reading frame P mutations increase expression of spliced or intron-containing ICP0 transcripts in mouse ganglia latently infected with herpes simplex virus.
Authors: Authors: Chen SH, Lee LY, Garber DA, Schaffer PA, Knipe DM, Coen DM.
J Virol
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The enzymological basis for resistance of herpesvirus DNA polymerase mutants to acyclovir: relationship to the structure of alpha-like DNA polymerases.
Authors: Authors: Huang L, Ishii KK, Zuccola H, Gehring AM, Hwang CB, Hogle J, Coen DM.
Proc Natl Acad Sci U S A
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Translational recoding induced by G-rich mRNA sequences that form unusual structures.
Authors: Authors: Horsburgh BC, Kollmus H, Hauser H, Coen DM.
Cell
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A net +1 frameshift permits synthesis of thymidine kinase from a drug-resistant herpes simplex virus mutant.
Authors: Authors: Hwang CB, Horsburgh B, Pelosi E, Roberts S, Digard P, Coen DM.
Proc Natl Acad Sci U S A
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A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells.
Authors: Authors: Sullivan V, Talarico CL, Stanat SC, Davis M, Coen DM, Biron KK.
Nature
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Specific inhibitors of herpes simplex virus thymidine kinase diminish reactivation of latent virus from explanted murine ganglia.
Authors: Authors: Leib DA, Ruffner KL, Hildebrand C, Schaffer PA, Wright GE, Coen DM.
Antimicrob Agents Chemother
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Analysis of the transcript of the herpes simplex virus DNA polymerase gene provides evidence that polymerase expression is inefficient at the level of translation.
Authors: Authors: Yager DR, Coen DM.
J Virol
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Genetic analysis of temperature-sensitive mutants of HSV-1: the combined use of complementation and physical mapping for cistron assignment.
Authors: Authors: Weller SK, Aschman DP, Sacks WR, Coen DM, Schaffer PA.
Virology
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