Douglas Melton, PhD
Xander University Professor of Stem Cell and Regenerative Biology, Faculty of Arts & Sciences
A Nutrient-Sensing Transition at Birth Triggers Glucose-Responsive Insulin Secretion.
Authors: Authors: Helman A, Cangelosi AL, Davis JC, Pham Q, Rothman A, Faust AL, Straubhaar JR, Sabatini DM, Melton DA.
Cell Metab
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Cell Metab
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Apolipoprotein E is a pancreatic extracellular factor that maintains mature ß-cell gene expression.
Authors: Authors: Mahmoud AI, Galdos FX, Dinan KA, Jedrychowski MP, Davis JC, Vujic A, Rachmin I, Shigley C, Pancoast JR, Lee S, Hollister-Lock J, MacGillivray CM, Gygi SP, Melton DA, Weir GC, Lee RT.
PLoS One
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PLoS One
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MARIS: method for analyzing RNA following intracellular sorting.
Authors: Authors: Hrvatin S, Deng F, O'Donnell CW, Gifford DK, Melton DA.
PLoS One
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PLoS One
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Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal.
Authors: Authors: Niakan KK, Ji H, Maehr R, Vokes SA, Rodolfa KT, Sherwood RI, Yamaki M, Dimos JT, Chen AE, Melton DA, McMahon AP, Eggan K.
Genes Dev
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Genes Dev
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All beta cells contribute equally to islet growth and maintenance.
Notch signaling controls multiple steps of pancreatic differentiation.
Authors: Authors: Murtaugh LC, Stanger BZ, Kwan KM, Melton DA.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Development of the pancreas in Xenopus laevis.
A molecular mechanism for the effect of lithium on development.
Processed Vg1 protein is an axial mesoderm inducer in Xenopus.
A two-step model for the localization of maternal mRNA in Xenopus oocytes: involvement of microtubules and microfilaments in the translocation and anchoring of Vg1 mRNA.