Douglas Melton, PhD
Xander University Professor of Stem Cell and Regenerative Biology, Faculty of Arts & Sciences
Beta-catenin is essential for pancreatic acinar but not islet development.
Genes, signals, and lineages in pancreas development.
Vertebrate endoderm development.
Induction of dorsal mesoderm by soluble, mature Vg1 protein.
Vegetal messenger RNA localization directed by a 340-nt RNA sequence element in Xenopus oocytes.
Bimodal and graded expression of the Xenopus homeobox gene Xhox3 during embryonic development.
Synchronized stimulation and continuous insulin sensing in a microfluidic human Islet on a Chip designed for scalable manufacturing.
Authors: Authors: Glieberman AL, Pope BD, Zimmerman JF, Liu Q, Ferrier JP, Kenty JHR, Schrell AM, Mukhitov N, Shores KL, Tepole AB, Melton DA, Roper MG, Parker KK.
Lab Chip
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Lab Chip
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Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice.
Authors: Authors: Vegas AJ, Veiseh O, Gürtler M, Millman JR, Pagliuca FW, Bader AR, Doloff JC, Li J, Chen M, Olejnik K, Tam HH, Jhunjhunwala S, Langan E, Aresta-Dasilva S, Gandham S, McGarrigle JJ, Bochenek MA, Hollister-Lock J, Oberholzer J, Greiner DL, Weir GC, Melton DA, Langer R, Anderson DG.
Nat Med
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Nat Med
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New findings in pancreatic and intestinal endocrine development to advance regenerative medicine.
Authors: Authors: Carolan PJ, Melton DA.
Curr Opin Endocrinol Diabetes Obes
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Curr Opin Endocrinol Diabetes Obes
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Transcriptional dynamics of endodermal organ formation.