Douglas Melton, PhD
Xander University Professor of Stem Cell and Regenerative Biology, Faculty of Arts & Sciences
Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation.
Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genes.
Pancreas development in the chick embryo.
Authors: Authors: Kim SK, Hebrok M, Melton DA.
Cold Spring Harb Symp Quant Biol
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Cold Spring Harb Symp Quant Biol
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Inhibition of activin receptor signaling promotes neuralization in Xenopus.
Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures.
Authors: Authors: Thomsen G, Woolf T, Whitman M, Sokol S, Vaughan J, Vale W, Melton DA.
Cell
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Cell
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Microinjection of synthetic Xhox-1A homeobox mRNA disrupts somite formation in developing Xenopus embryos.