Ed Harlow

Ed Harlow, PhD

Virginia and D.K. Ludwig Professor of Cancer Research and Teaching, Harvard Medical School

Dr. Edward (Ed) E. Harlow, Jr. Ph.D. is a distinguished molecular biologist and an internationally recognized leader in cancer biology, who is best known for his discoveries regarding the control of cell division and critical changes that allow cancer to develop.  He currently splits his time between an appointment as Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School and Senior Advisor to the Director, National Cancer Institute.  He served as Chief Scientific Officer of Constellation Pharmaceuticals, Inc. from 2009 to 2011.  From 1998 to 2009, he served as Professor and Chair of the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School and was Associate Director of the Dana-Farber/Harvard Cancer Center.  From 1990 to 1998, he served as Scientific Director for the Massachusetts General Hospital Cancer Center and was Associate Director for Science Policy at the National Cancer Institute, where he helped direct U.S. cancer research planning.  Prior to 1990, Dr. Harlow served on the faculty of Cold Spring Harbor Laboratory.  Dr. Harlow has served on a number of influential advisory groups, including the Board of Life Sciences for the National Research Council, External Advisory Boards for UCSF, Stanford, UCLA, and NYU Cancer Centers and the Scientific Advisory Board for the Foundation for Advanced Cancer Studies.  He has chaired or served on numerous biotechnology and pharmaceutical companies advisory boards, including Onyx, 3V Biosciences, Alnylam, and Pfizer Pharmaceuticals. Dr. Harlow has received numerous scientific honors, including election to the National Academy of Sciences in 1993 and the Institute of Medicine in 1999, appointment as Fellow of the American Academy of Arts and Sciences, and recipient of the American Cancer Society's highest award, the Medal of Honor. Dr. Harlow with Dr. David Lane are co-authors of one of the all time best-selling research manuals, Antibodies: A laboratory manual.  Dr. Harlow received his B.S. and M.S. from the University of Oklahoma and his Ph.D. at the Imperial Cancer Research Fund in London in 1982.

A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells.
Authors: Authors: Giordano A, Whyte P, Harlow E, Franza BR, Beach D, Draetta G.
Cell
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Association of a murine 53,000-dalton phosphoprotein with simian virus 40 large-T antigen in transformed cells.
Authors: Authors: McCormick F, Harlow E.
J Virol
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Identification of small molecule inhibitors of pyruvate kinase M2.
Authors: Authors: Vander Heiden MG, Christofk HR, Schuman E, Subtelny AO, Sharfi H, Harlow EE, Xian J, Cantley LC.
Biochem Pharmacol
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Histone deacetylase-dependent transcriptional repression by pRB in yeast occurs independently of interaction through the LXCXE binding cleft.
Authors: Authors: Kennedy BK, Liu OW, Dick FA, Dyson N, Harlow E, Vidal M.
Proc Natl Acad Sci U S A
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Specific regulation of E2F family members by cyclin-dependent kinases.
Authors: Authors: Dynlacht BD, Moberg K, Lees JA, Harlow E, Zhu L.
Mol Cell Biol
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Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition.
Authors: Authors: Koh J, Enders GH, Dynlacht BD, Harlow E.
Nature
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Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation.
Authors: Authors: Helin K, Wu CL, Fattaey AR, Lees JA, Dynlacht BD, Ngwu C, Harlow E.
Genes Dev
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Interaction of p107 with cyclin A independent of complex formation with viral oncoproteins.
Authors: Authors: Ewen ME, Faha B, Harlow E, Livingston DM.
Science
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The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus.
Authors: Authors: Dyson N, Buchkovich K, Whyte P, Harlow E.
Cell
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Characterization of the complex between SV40 large T antigen and the 53K host protein in transformed mouse cells.
Authors: Authors: Crawford LV, Lane DP, Denhardt DT, Harlow EE, Nicklin PM, Osborn K, Pim DC.
Cold Spring Harb Symp Quant Biol
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