Ed Harlow

Ed Harlow, PhD

Virginia and D.K. Ludwig Professor of Cancer Research and Teaching, Harvard Medical School

Dr. Edward (Ed) E. Harlow, Jr. Ph.D. is a distinguished molecular biologist and an internationally recognized leader in cancer biology, who is best known for his discoveries regarding the control of cell division and critical changes that allow cancer to develop.  He currently splits his time between an appointment as Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School and Senior Advisor to the Director, National Cancer Institute.  He served as Chief Scientific Officer of Constellation Pharmaceuticals, Inc. from 2009 to 2011.  From 1998 to 2009, he served as Professor and Chair of the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School and was Associate Director of the Dana-Farber/Harvard Cancer Center.  From 1990 to 1998, he served as Scientific Director for the Massachusetts General Hospital Cancer Center and was Associate Director for Science Policy at the National Cancer Institute, where he helped direct U.S. cancer research planning.  Prior to 1990, Dr. Harlow served on the faculty of Cold Spring Harbor Laboratory.  Dr. Harlow has served on a number of influential advisory groups, including the Board of Life Sciences for the National Research Council, External Advisory Boards for UCSF, Stanford, UCLA, and NYU Cancer Centers and the Scientific Advisory Board for the Foundation for Advanced Cancer Studies.  He has chaired or served on numerous biotechnology and pharmaceutical companies advisory boards, including Onyx, 3V Biosciences, Alnylam, and Pfizer Pharmaceuticals. Dr. Harlow has received numerous scientific honors, including election to the National Academy of Sciences in 1993 and the Institute of Medicine in 1999, appointment as Fellow of the American Academy of Arts and Sciences, and recipient of the American Cancer Society's highest award, the Medal of Honor. Dr. Harlow with Dr. David Lane are co-authors of one of the all time best-selling research manuals, Antibodies: A laboratory manual.  Dr. Harlow received his B.S. and M.S. from the University of Oklahoma and his Ph.D. at the Imperial Cancer Research Fund in London in 1982.

Genetic characterization of a mammalian protein-protein interaction domain by using a yeast reverse two-hybrid system.
Authors: Authors: Vidal M, Braun P, Chen E, Boeke JD, Harlow E.
Proc Natl Acad Sci U S A
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p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5.
Authors: Authors: Tsai LH, Delalle I, Caviness VS, Chae T, Harlow E.
Nature
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The adenovirus E1A-associated kinase consists of cyclin E-p33cdk2 and cyclin A-p33cdk2.
Authors: Authors: Faha B, Harlow E, Lees E.
J Virol
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Cell cycle regulation of histone H1 kinase activity associated with the adenoviral protein E1A.
Authors: Authors: Giordano A, Lee JH, Scheppler JA, Herrmann C, Harlow E, Deuschle U, Beach D, Franza BR.
Science
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Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product.
Authors: Authors: Whyte P, Buchkovich KJ, Horowitz JM, Friend SH, Raybuck M, Weinberg RA, Harlow E.
Nature
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Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.
Authors: Authors: Hu Y, Rolfs A, Bhullar B, Murthy TV, Zhu C, Berger MF, Camargo AA, Kelley F, McCarron S, Jepson D, Richardson A, Raphael J, Moreira D, Taycher E, Zuo D, Mohr S, Kane MF, Williamson J, Simpson A, Bulyk ML, Harlow E, Marsischky G, Kolodner RD, LaBaer J.
Genome Res
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Combinatorial roles for pRB, p107, and p130 in E2F-mediated cell cycle control.
Authors: Authors: Classon M, Salama S, Gorka C, Mulloy R, Braun P, Harlow E.
Proc Natl Acad Sci U S A
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Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions.
Authors: Authors: Vidal M, Brachmann RK, Fattaey A, Harlow E, Boeke JD.
Proc Natl Acad Sci U S A
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Heterodimerization of the transcription factors E2F-1 and DP-1 is required for binding to the adenovirus E4 (ORF6/7) protein.
Authors: Authors: Helin K, Harlow E.
J Virol
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Sequences within the conserved cyclin box of human cyclin A are sufficient for binding to and activation of cdc2 kinase.
Authors: Authors: Lees EM, Harlow E.
Mol Cell Biol
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