Ed Harlow

Ed Harlow, PhD

Virginia and D.K. Ludwig Professor of Cancer Research and Teaching, Harvard Medical School

Dr. Edward (Ed) E. Harlow, Jr. Ph.D. is a distinguished molecular biologist and an internationally recognized leader in cancer biology, who is best known for his discoveries regarding the control of cell division and critical changes that allow cancer to develop.  He currently splits his time between an appointment as Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School and Senior Advisor to the Director, National Cancer Institute.  He served as Chief Scientific Officer of Constellation Pharmaceuticals, Inc. from 2009 to 2011.  From 1998 to 2009, he served as Professor and Chair of the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School and was Associate Director of the Dana-Farber/Harvard Cancer Center.  From 1990 to 1998, he served as Scientific Director for the Massachusetts General Hospital Cancer Center and was Associate Director for Science Policy at the National Cancer Institute, where he helped direct U.S. cancer research planning.  Prior to 1990, Dr. Harlow served on the faculty of Cold Spring Harbor Laboratory.  Dr. Harlow has served on a number of influential advisory groups, including the Board of Life Sciences for the National Research Council, External Advisory Boards for UCSF, Stanford, UCLA, and NYU Cancer Centers and the Scientific Advisory Board for the Foundation for Advanced Cancer Studies.  He has chaired or served on numerous biotechnology and pharmaceutical companies advisory boards, including Onyx, 3V Biosciences, Alnylam, and Pfizer Pharmaceuticals. Dr. Harlow has received numerous scientific honors, including election to the National Academy of Sciences in 1993 and the Institute of Medicine in 1999, appointment as Fellow of the American Academy of Arts and Sciences, and recipient of the American Cancer Society's highest award, the Medal of Honor. Dr. Harlow with Dr. David Lane are co-authors of one of the all time best-selling research manuals, Antibodies: A laboratory manual.  Dr. Harlow received his B.S. and M.S. from the University of Oklahoma and his Ph.D. at the Imperial Cancer Research Fund in London in 1982.

Disruption of retinoblastoma protein family function by human papillomavirus type 16 E7 oncoprotein inhibits lens development in part through E2F-1.
Authors: Authors: McCaffrey J, Yamasaki L, Dyson NJ, Harlow E, Griep AE.
Mol Cell Biol
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Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members.
Authors: Authors: Magae J, Wu CL, Illenye S, Harlow E, Heintz NH.
J Cell Sci
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Identification of G1 kinase activity for cdk6, a novel cyclin D partner.
Authors: Authors: Meyerson M, Harlow E.
Mol Cell Biol
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Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner.
Authors: Authors: Lees E, Faha B, Dulic V, Reed SI, Harlow E.
Genes Dev
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The cyclin-dependent kinase family.
Authors: Authors: Meyerson M, Faha B, Su LK, Harlow E, Tsai LH.
Cold Spring Harb Symp Quant Biol
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Differential splicing yields novel adenovirus 5 E1A mRNAs that encode 30 kd and 35 kd proteins.
Authors: Authors: Stephens C, Harlow E.
EMBO J
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GRK3 is essential for metastatic cells and promotes prostate tumor progression.
Authors: Authors: Li W, Ai N, Wang S, Bhattacharya N, Vrbanac V, Collins M, Signoretti S, Hu Y, Boyce FM, Gravdal K, Halvorsen OJ, Nalwoga H, Akslen LA, Harlow E, Watnick RS.
Proc Natl Acad Sci U S A
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A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation.
Authors: Authors: Johnson BR, Nitta RT, Frock RL, Mounkes L, Barbie DA, Stewart CL, Harlow E, Kennedy BK.
Proc Natl Acad Sci U S A
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No effect of loss of E2F1 on liver regeneration or hepatocarcinogenesis in C57BL/6J or C3H/HeJ mice.
Authors: Authors: Lukas ER, Bartley SM, Graveel CR, Diaz ZM, Dyson N, Harlow E, Yamasaki L, Farnham PJ.
Mol Carcinog
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Expression of the retinoblastoma protein in low-grade B-cell lymphoma: relationship to cyclin D1.
Authors: Authors: Zukerberg LR, Benedict WF, Arnold A, Dyson N, Harlow E, Harris NL.
Blood
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