Eric Fischer, PhD

Assistant Professor of Biological Chemistry and Molecular Pharmacology, Dana-Farber Cancer Institute
Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome.
Authors: Authors: Donovan KA, An J, Nowak RP, Yuan JC, Fink EC, Berry BC, Ebert BL, Fischer ES.
Elife
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The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation.
Authors: Authors: Fischer ES, Scrima A, Böhm K, Matsumoto S, Lingaraju GM, Faty M, Yasuda T, Cavadini S, Wakasugi M, Hanaoka F, Iwai S, Gut H, Sugasawa K, Thomä NH.
Cell
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Genome-wide screen identifies cullin-RING ligase machinery required for lenalidomide-dependent CRL4CRBN activity.
Authors: Authors: Sievers QL, Gasser JA, Cowley GS, Fischer ES, Ebert BL.
Blood
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Detecting UV-lesions in the genome: The modular CRL4 ubiquitin ligase does it best!
Authors: Authors: Scrima A, Fischer ES, Lingaraju GM, Böhm K, Cavadini S, Thomä NH.
FEBS Lett
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Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance.
Authors: Authors: Zhou W, Whiteley AT, de Oliveira Mann CC, Morehouse BR, Nowak RP, Fischer ES, Gray NS, Mekalanos JJ, Kranzusch PJ.
Cell
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Plasticity in binding confers selectivity in ligand-induced protein degradation.
Authors: Authors: Nowak RP, DeAngelo SL, Buckley D, He Z, Donovan KA, An J, Safaee N, Jedrychowski MP, Ponthier CM, Ishoey M, Zhang T, Mancias JD, Gray NS, Bradner JE, Fischer ES.
Nat Chem Biol
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Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK).
Authors: Authors: Powell CE, Gao Y, Tan L, Donovan KA, Nowak RP, Loehr A, Bahcall M, Fischer ES, Jänne PA, George RE, Gray NS.
J Med Chem
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ER Stress Signaling Promotes the Survival of Cancer "Persister Cells" Tolerant to EGFR Tyrosine Kinase Inhibitors.
Authors: Authors: Terai H, Kitajima S, Potter DS, Matsui Y, Quiceno LG, Chen T, Kim TJ, Rusan M, Thai TC, Piccioni F, Donovan KA, Kwiatkowski N, Hinohara K, Wei G, Gray NS, Fischer ES, Wong KK, Shimamura T, Letai A, Hammerman PS, Barbie DA.
Cancer Res
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Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation.
Authors: Authors: Olson CM, Jiang B, Erb MA, Liang Y, Doctor ZM, Zhang Z, Zhang T, Kwiatkowski N, Boukhali M, Green JL, Haas W, Nomanbhoy T, Fischer ES, Young RA, Bradner JE, Winter GE, Gray NS.
Nat Chem Biol
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A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader.
Authors: Authors: Huang HT, Dobrovolsky D, Paulk J, Yang G, Weisberg EL, Doctor ZM, Buckley DL, Cho JH, Ko E, Jang J, Shi K, Choi HG, Griffin JD, Li Y, Treon SP, Fischer ES, Bradner JE, Tan L, Gray NS.
Cell Chem Biol
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