Eric Fischer, PhD

Assistant Professor of Biological Chemistry and Molecular Pharmacology, Dana-Farber Cancer Institute
Functional regulation of the DNA damage-recognition factor DDB2 by ubiquitination and interaction with xeroderma pigmentosum group C protein.
Authors: Authors: Matsumoto S, Fischer ES, Yasuda T, Dohmae N, Iwai S, Mori T, Nishi R, Yoshino K, Sakai W, Hanaoka F, Thomä NH, Sugasawa K.
Nucleic Acids Res
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Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML.
Authors: Authors: Brand M, Jiang B, Bauer S, Donovan KA, Liang Y, Wang ES, Nowak RP, Yuan JC, Zhang T, Kwiatkowski N, Müller AC, Fischer ES, Gray NS, Winter GE.
Cell Chem Biol
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Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide.
Authors: Authors: Fischer ES, Böhm K, Lydeard JR, Yang H, Stadler MB, Cavadini S, Nagel J, Serluca F, Acker V, Lingaraju GM, Tichkule RB, Schebesta M, Forrester WC, Schirle M, Hassiepen U, Ottl J, Hild M, Beckwith RE, Harper JW, Jenkins JL, Thomä NH.
Nature
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Bruton tyrosine kinase degradation as a therapeutic strategy for cancer.
Authors: Authors: Dobrovolsky D, Wang ES, Morrow S, Leahy C, Faust T, Nowak RP, Donovan KA, Yang G, Li Z, Fischer ES, Treon SP, Weinstock DM, Gray NS.
Blood
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Crystal structure of the human COP9 signalosome.
Authors: Authors: Lingaraju GM, Bunker RD, Cavadini S, Hess D, Hassiepen U, Renatus M, Fischer ES, Thomä NH.
Nature
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Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome.
Authors: Authors: Donovan KA, An J, Nowak RP, Yuan JC, Fink EC, Berry BC, Ebert BL, Fischer ES.
Elife
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The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation.
Authors: Authors: Fischer ES, Scrima A, Böhm K, Matsumoto S, Lingaraju GM, Faty M, Yasuda T, Cavadini S, Wakasugi M, Hanaoka F, Iwai S, Gut H, Sugasawa K, Thomä NH.
Cell
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Genome-wide screen identifies cullin-RING ligase machinery required for lenalidomide-dependent CRL4CRBN activity.
Authors: Authors: Sievers QL, Gasser JA, Cowley GS, Fischer ES, Ebert BL.
Blood
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Detecting UV-lesions in the genome: The modular CRL4 ubiquitin ligase does it best!
Authors: Authors: Scrima A, Fischer ES, Lingaraju GM, Böhm K, Cavadini S, Thomä NH.
FEBS Lett
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Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance.
Authors: Authors: Zhou W, Whiteley AT, de Oliveira Mann CC, Morehouse BR, Nowak RP, Fischer ES, Gray NS, Mekalanos JJ, Kranzusch PJ.
Cell
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