Eric Fischer, PhD

Assistant Professor of Biological Chemistry and Molecular Pharmacology, Dana-Farber Cancer Institute
Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML.
Authors: Authors: Brand M, Jiang B, Bauer S, Donovan KA, Liang Y, Wang ES, Nowak RP, Yuan JC, Zhang T, Kwiatkowski N, Müller AC, Fischer ES, Gray NS, Winter GE.
Cell Chem Biol
View full abstract on Pubmed
Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide.
Authors: Authors: Fischer ES, Böhm K, Lydeard JR, Yang H, Stadler MB, Cavadini S, Nagel J, Serluca F, Acker V, Lingaraju GM, Tichkule RB, Schebesta M, Forrester WC, Schirle M, Hassiepen U, Ottl J, Hild M, Beckwith RE, Harper JW, Jenkins JL, Thomä NH.
Nature
View full abstract on Pubmed
Bruton tyrosine kinase degradation as a therapeutic strategy for cancer.
Authors: Authors: Dobrovolsky D, Wang ES, Morrow S, Leahy C, Faust T, Nowak RP, Donovan KA, Yang G, Li Z, Fischer ES, Treon SP, Weinstock DM, Gray NS.
Blood
View full abstract on Pubmed
Crystal structure of the human COP9 signalosome.
Authors: Authors: Lingaraju GM, Bunker RD, Cavadini S, Hess D, Hassiepen U, Renatus M, Fischer ES, Thomä NH.
Nature
View full abstract on Pubmed
Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome.
Authors: Authors: Donovan KA, An J, Nowak RP, Yuan JC, Fink EC, Berry BC, Ebert BL, Fischer ES.
Elife
View full abstract on Pubmed
The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation.
Authors: Authors: Fischer ES, Scrima A, Böhm K, Matsumoto S, Lingaraju GM, Faty M, Yasuda T, Cavadini S, Wakasugi M, Hanaoka F, Iwai S, Gut H, Sugasawa K, Thomä NH.
Cell
View full abstract on Pubmed
Genome-wide screen identifies cullin-RING ligase machinery required for lenalidomide-dependent CRL4CRBN activity.
Authors: Authors: Sievers QL, Gasser JA, Cowley GS, Fischer ES, Ebert BL.
Blood
View full abstract on Pubmed
Detecting UV-lesions in the genome: The modular CRL4 ubiquitin ligase does it best!
Authors: Authors: Scrima A, Fischer ES, Lingaraju GM, Böhm K, Cavadini S, Thomä NH.
FEBS Lett
View full abstract on Pubmed
Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance.
Authors: Authors: Zhou W, Whiteley AT, de Oliveira Mann CC, Morehouse BR, Nowak RP, Fischer ES, Gray NS, Mekalanos JJ, Kranzusch PJ.
Cell
View full abstract on Pubmed
Plasticity in binding confers selectivity in ligand-induced protein degradation.
Authors: Authors: Nowak RP, DeAngelo SL, Buckley D, He Z, Donovan KA, An J, Safaee N, Jedrychowski MP, Ponthier CM, Ishoey M, Zhang T, Mancias JD, Gray NS, Bradner JE, Fischer ES.
Nat Chem Biol
View full abstract on Pubmed