Guangyan Du, PhD

Research Fellow in Biological Chemistry and Molecular Pharmacology (EXT), Dana-Farber Cancer Institute
A multitargeted probe-based strategy to identify signaling vulnerabilities in cancers.
Authors: Authors: Rao S, Du G, Hafner M, Subramanian K, Sorger PK, Gray NS.
J Biol Chem
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Specific covalent inhibition of MALT1 paracaspase suppresses B cell lymphoma growth.
Authors: Authors: Fontán L, Qiao Q, Hatcher JM, Casalena G, Us I, Teater M, Durant M, Du G, Xia M, Bilchuk N, Chennamadhavuni S, Palladino G, Inghirami G, Philippar U, Wu H, Scott DA, Gray NS, Melnick A.
J Clin Invest
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Structure-guided development of covalent TAK1 inhibitors.
Authors: Authors: Tan L, Gurbani D, Weisberg EL, Hunter JC, Li L, Jones DS, Ficarro SB, Mowafy S, Tam CP, Rao S, Du G, Griffin JD, Sorger PK, Marto JA, Westover KD, Gray NS.
Bioorg Med Chem
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Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors.
Authors: Authors: Tan L, Gurbani D, Weisberg EL, Jones DS, Rao S, Singer WD, Bernard FM, Mowafy S, Jenney A, Du G, Nonami A, Griffin JD, Lauffenburger DA, Westover KD, Sorger PK, Gray NS.
Bioorg Med Chem
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Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations.
Authors: Authors: de Wispelaere M, Du G, Donovan KA, Zhang T, Eleuteri NA, Yuan JC, Kalabathula J, Nowak RP, Fischer ES, Gray NS, Yang PL.
Nat Commun
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Quinoline and thiazolopyridine allosteric inhibitors of MALT1.
Authors: Authors: Scott DA, Hatcher JM, Liu H, Fu M, Du G, Fontán L, Us I, Casalena G, Qiao Q, Wu H, Melnick A, Gray NS.
Bioorg Med Chem Lett
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Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome.
Authors: Authors: Rao S, Gurbani D, Du G, Everley RA, Browne CM, Chaikuad A, Tan L, Schröder M, Gondi S, Ficarro SB, Sim T, Kim ND, Berberich MJ, Knapp S, Marto JA, Westover KD, Sorger PK, Gray NS.
Cell Chem Biol
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Peptide-based covalent inhibitors of MALT1 paracaspase.
Authors: Authors: Hatcher JM, Du G, Fontán L, Us I, Qiao Q, Chennamadhavuni S, Shao J, Wu H, Melnick A, Gray NS, Scott DA.
Bioorg Med Chem Lett
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