Haribabu Arthanari, PhD

Assistant Professor of Biological Chemistry and Molecular Pharmacology, Dana-Farber Cancer Institute
Molecular mechanism of the dual activity of 4EGI-1: Dissociating eIF4G from eIF4E but stabilizing the binding of unphosphorylated 4E-BP1.
Authors: Authors: Sekiyama N, Arthanari H, Papadopoulos E, Rodriguez-Mias RA, Wagner G, Léger-Abraham M.
Proc Natl Acad Sci U S A
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The kinetochore-bound Ska1 complex tracks depolymerizing microtubules and binds to curved protofilaments.
Authors: Authors: Schmidt JC, Arthanari H, Boeszoermenyi A, Dashkevich NM, Wilson-Kubalek EM, Monnier N, Markus M, Oberer M, Milligan RA, Bathe M, Wagner G, Grishchuk EL, Cheeseman IM.
Dev Cell
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Mediator subunit Gal11p/MED15 is required for fatty acid-dependent gene activation by yeast transcription factor Oaf1p.
Authors: Authors: Thakur JK, Arthanari H, Yang F, Chau KH, Wagner G, Näär AM.
J Biol Chem
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CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation.
Authors: Authors: Deng J, Wang ES, Jenkins RW, Li S, Dries R, Yates K, Chhabra S, Huang W, Liu H, Aref AR, Ivanova E, Paweletz CP, Bowden M, Zhou CW, Herter-Sprie GS, Sorrentino JA, Bisi JE, Lizotte PH, Merlino AA, Quinn MM, Bufe LE, Yang A, Zhang Y, Zhang H, Gao P, Chen T, Cavanaugh ME, Rode AJ, Haines E, Roberts PJ, Strum JC, Richards WG, Lorch JH, Parangi S, Gunda V, Boland GM, Bueno R, Palakurthi S, Freeman GJ, Ritz J, Haining WN, Sharpless NE, Arthanari H, Shapiro GI, Barbie DA, Gray NS, Wong KK.
Cancer Discov
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Structure of a herpesvirus nuclear egress complex subunit reveals an interaction groove that is essential for viral replication.
Authors: Authors: Leigh KE, Sharma M, Mansueto MS, Boeszoermenyi A, Filman DJ, Hogle JM, Wagner G, Coen DM, Arthanari H.
Proc Natl Acad Sci U S A
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The C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2ß.
Authors: Authors: Luna RE, Arthanari H, Hiraishi H, Nanda J, Martin-Marcos P, Markus MA, Akabayov B, Milbradt AG, Luna LE, Seo HC, Hyberts SG, Fahmy A, Reibarkh M, Miles D, Hagner PR, O'Day EM, Yi T, Marintchev A, Hinnebusch AG, Lorsch JR, Asano K, Wagner G.
Cell Rep
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Dynamic thiolation-thioesterase structure of a non-ribosomal peptide synthetase.
Authors: Authors: Frueh DP, Arthanari H, Koglin A, Vosburg DA, Bennett AE, Walsh CT, Wagner G.
Nature
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N-Acyl Homoserine Lactone Analog Modulators of the Pseudomonas aeruginosa Rhll Quorum Sensing Signal Synthase.
Authors: Authors: Shin D, Gorgulla C, Boursier ME, Rexrode N, Brown EC, Arthanari H, Blackwell HE, Nagarajan R.
ACS Chem Biol
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NMR-directed design of pre-TCRß and pMHC molecules implies a distinct geometry for pre-TCR relative to aßTCR recognition of pMHC.
Authors: Authors: Mallis RJ, Arthanari H, Lang MJ, Reinherz EL, Wagner G.
J Biol Chem
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Pre-TCR ligand binding impacts thymocyte development before aßTCR expression.
Authors: Authors: Mallis RJ, Bai K, Arthanari H, Hussey RE, Handley M, Li Z, Chingozha L, Duke-Cohan JS, Lu H, Wang JH, Zhu C, Wagner G, Reinherz EL.
Proc Natl Acad Sci U S A
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