James Hogle, PhD

Edward S. Harkness Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
The crystal structure of an unusual processivity factor, herpes simplex virus UL42, bound to the C terminus of its cognate polymerase.
Authors: Authors: Zuccola HJ, Filman DJ, Coen DM, Hogle JM.
Mol Cell
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A pseudo-cell based approach to efficient crystallographic refinement of viruses.
Authors: Authors: Jacobson DH, Hogle JM, Filman DJ.
Acta Crystallogr D Biol Crystallogr
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A mutation in VP4 defines a new step in the late stages of cell entry by poliovirus.
Authors: Authors: Moscufo N, Yafal AG, Rogove A, Hogle J, Chow M.
J Virol
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Engineering a poliovirus type 2 antigenic site on a type 1 capsid results in a chimaeric virus which is neurovirulent for mice.
Authors: Authors: Martin A, Wychowski C, Couderc T, Crainic R, Hogle J, Girard M.
EMBO J
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Mechanism of action and capsid-stabilizing properties of VHHs with an in vitro antipolioviral activity.
Authors: Authors: Schotte L, Strauss M, Thys B, Halewyck H, Filman DJ, Bostina M, Hogle JM, Rombaut B.
J Virol
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Post-imaging fiducial markers aid in the orientation determination of complexes with mixed or unknown symmetry.
Authors: Authors: Bubeck D, Filman DJ, Kuzmin M, Fuller SD, Hogle JM.
J Struct Biol
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Residues of human cytomegalovirus DNA polymerase catalytic subunit UL54 that are necessary and sufficient for interaction with the accessory protein UL44.
Authors: Authors: Loregian A, Appleton BA, Hogle JM, Coen DM.
J Virol
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Three-dimensional structure of poliovirus receptor bound to poliovirus.
Authors: Authors: Belnap DM, McDermott BM, Filman DJ, Cheng N, Trus BL, Zuccola HJ, Racaniello VR, Hogle JM, Steven AC.
Proc Natl Acad Sci U S A
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A genetic algorithm for the ab initio phasing of icosahedral viruses.
Authors: Authors: Miller ST, Hogle JM, Filman DJ.
Acta Crystallogr D Biol Crystallogr
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Molecular characterization of mouse-virulent poliovirus type 1 Mahoney mutants: involvement of residues of polypeptides VP1 and VP2 located on the inner surface of the capsid protein shell.
Authors: Authors: Couderc T, Hogle J, Le Blay H, Horaud F, Blondel B.
J Virol
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