James Hogle, PhD

Edward S. Harkness Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Poliovirus neutralization by antibodies to internal epitopes of VP4 and VP1 results from reversible exposure of these sequences at physiological temperature.
Authors: Authors: Li Q, Yafal AG, Lee YM, Hogle J, Chow M.
J Virol
View full abstract on Pubmed
Alteration of amino acid 101 within capsid protein VP-1 changes the pathogenicity of Theiler's murine encephalomyelitis virus.
Authors: Authors: Zurbriggen A, Hogle JM, Fujinami RS.
J Exp Med
View full abstract on Pubmed
Generation of protein-reactive antibodies by short peptides is an event of high frequency: implications for the structural basis of immune recognition.
Authors: Authors: Niman HL, Houghten RA, Walker LE, Reisfeld RA, Wilson IA, Hogle JM, Lerner RA.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Characterization of Poliovirus Neutralization Escape Mutants of Single-Domain Antibody Fragments (VHHs).
Authors: Authors: Schotte L, Thys B, Strauss M, Filman DJ, Rombaut B, Hogle JM.
Antimicrob Agents Chemother
View full abstract on Pubmed
The crystal structure of PF-8, the DNA polymerase accessory subunit from Kaposi's sarcoma-associated herpesvirus.
Authors: Authors: Baltz JL, Filman DJ, Ciustea M, Silverman JE, Lautenschlager CL, Coen DM, Ricciardi RP, Hogle JM.
J Virol
View full abstract on Pubmed
Cryo-electron microscopy reconstruction of a poliovirus-receptor-membrane complex.
Authors: Authors: Bubeck D, Filman DJ, Hogle JM.
Nat Struct Mol Biol
View full abstract on Pubmed
Is the 135S poliovirus particle an intermediate during cell entry?
Authors: Authors: Huang Y, Hogle JM, Chow M.
J Virol
View full abstract on Pubmed
Structural studies of poliovirus mutants that overcome receptor defects.
Authors: Authors: Wien MW, Curry S, Filman DJ, Hogle JM.
Nat Struct Biol
View full abstract on Pubmed
Chimeric Theiler's virus with altered tropism for the central nervous system.
Authors: Authors: Jarousse N, Fiette L, Grant RA, Hogle JM, McAllister A, Michiels T, Aubert C, Tangy F, Brahic M, Peña Rossi C.
J Virol
View full abstract on Pubmed
The antigenic structure of poliovirus.
Authors: Authors: Hogle JM, Filman DJ.
Philos Trans R Soc Lond B Biol Sci
View full abstract on Pubmed