James Hogle, PhD

Edward S. Harkness Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Substitutions in the capsids of poliovirus mutants selected in human neuroblastoma cells confer on the Mahoney type 1 strain a phenotype neurovirulent in mice.
Authors: Authors: Couderc T, Guédo N, Calvez V, Pelletier I, Hogle J, Colbère-Garapin F, Blondel B.
J Virol
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Virology. Architecture with a difference.
Authors: Authors: Filman DJ, Hogle JM.
Nature
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Three-dimensional structure of poliovirus at 2.9 A resolution.
Authors: Authors: Hogle JM, Chow M, Filman DJ.
Science
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Five of Five VHHs Neutralizing Poliovirus Bind the Receptor-Binding Site.
Authors: Authors: Strauss M, Schotte L, Thys B, Filman DJ, Hogle JM.
J Virol
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Poliovirus RNA is released from the capsid near a twofold symmetry axis.
Authors: Authors: Bostina M, Levy H, Filman DJ, Hogle JM.
J Virol
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Crystal structure of the cytomegalovirus DNA polymerase subunit UL44 in complex with the C terminus from the catalytic subunit. Differences in structure and function relative to unliganded UL44.
Authors: Authors: Appleton BA, Brooks J, Loregian A, Filman DJ, Coen DM, Hogle JM.
J Biol Chem
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A structurally biased combinatorial approach for discovering new anti-picornaviral compounds.
Authors: Authors: Tsang SK, Cheh J, Isaacs L, Joseph-McCarthy D, Choi SK, Pevear DC, Whitesides GM, Hogle JM.
Chem Biol
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Initiation of hepatitis delta virus genome replication.
Authors: Authors: Dingle K, Bichko V, Zuccola H, Hogle J, Taylor J.
J Virol
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Role and mechanism of the maturation cleavage of VP0 in poliovirus assembly: structure of the empty capsid assembly intermediate at 2.9 A resolution.
Authors: Authors: Basavappa R, Syed R, Flore O, Icenogle JP, Filman DJ, Hogle JM.
Protein Sci
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Neutralizing antibody to Mengo virus, induced by synthetic peptides.
Authors: Authors: Muir S, Weintraub JP, Hogle J, Bittle JL.
J Gen Virol
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