Johan Paulsson, PhD
Professor of Systems Biology, Harvard Medical School
Separating intrinsic from extrinsic fluctuations in dynamic biological systems.
Near-critical phenomena in intracellular metabolite pools.
Mechanical slowing-down of cytoplasmic diffusion allows in vivo counting of proteins in individual cells.
Authors: Authors: Okumus B, Landgraf D, Lai GC, Bakshi S, Arias-Castro JC, Yildiz S, Huh D, Fernandez-Lopez R, Peterson CN, Toprak E, El Karoui M, Paulsson J.
Nat Commun
View full abstract on Pubmed
Nat Commun
View full abstract on Pubmed
Non-genetic heterogeneity from stochastic partitioning at cell division.
Multileveled selection on plasmid replication.
Exploiting Natural Fluctuations to Identify Kinetic Mechanisms in Sparsely Characterized Systems.
Fundamental limits on the suppression of molecular fluctuations.
Origin pairing ('handcuffing') as a mode of negative control of P1 plasmid copy number.
Stochastic activation of a DNA damage response causes cell-to-cell mutation rate variation.
Authors: Authors: Uphoff S, Lord ND, Okumus B, Potvin-Trottier L, Sherratt DJ, Paulsson J.
Science
View full abstract on Pubmed
Science
View full abstract on Pubmed
Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicity.
Authors: Authors: Usui K, Hulleman JD, Paulsson JF, Siegel SJ, Powers ET, Kelly JW.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Proc Natl Acad Sci U S A
View full abstract on Pubmed