John Mekalanos, PhD
Adele Lehman Professor of Microbiology and Molecular Genetics, Harvard Medical School
Combining anthrax vaccine and therapy: a dominant-negative inhibitor of anthrax toxin is also a potent and safe immunogen for vaccines.
Authors: Authors: Aulinger BA, Roehrl MH, Mekalanos JJ, Collier RJ, Wang JY.
Infect Immun
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Infect Immun
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A dually active anthrax vaccine that confers protection against both bacilli and toxins.
Authors: Authors: Rhie GE, Roehrl MH, Mourez M, Collier RJ, Mekalanos JJ, Wang JY.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Vibrio cholerae-induced cellular responses of polarized T84 intestinal epithelial cells are dependent on production of cholera toxin and the RTX toxin.
Effects of changes in membrane sodium flux on virulence gene expression in Vibrio cholerae.
Replication and integration of a Vibrio cholerae cryptic plasmid linked to the CTX prophage.
Authors: Authors: Rubin EJ, Lin W, Mekalanos JJ, Waldor MK.
Mol Microbiol
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Mol Microbiol
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Quartz crystal microbalance detection of Vibrio cholerae O139 serotype.
Authors: Authors: Carter RM, Mekalanos JJ, Jacobs MB, Lubrano GJ, Guilbault GG.
J Immunol Methods
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J Immunol Methods
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Measurement of transcriptional activity in pathogenic bacteria recovered directly from infected host tissue.
Structural analysis of the acfA and acfD genes of Vibrio cholerae: effects of DNA topology and transcriptional activators on expression.
Evidence that modulation requires sequences downstream of the promoters of two vir-repressed genes of Bordetella pertussis.
Two trans-acting regulatory genes (vir and mod) control antigenic modulation in Bordetella pertussis.