John Mekalanos, PhD
Adele Lehman Professor of Microbiology and Molecular Genetics, Harvard Medical School
Identification of a vibrio cholerae RTX toxin gene cluster that is tightly linked to the cholera toxin prophage.
Authors: Authors: Lin W, Fullner KJ, Clayton R, Sexton JA, Rogers MB, Calia KE, Calderwood SB, Fraser C, Mekalanos JJ.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Use of signature-tagged transposon mutagenesis to identify Vibrio cholerae genes critical for colonization.
Single amino acid substitutions in the N-terminus of Vibrio cholerae TcpA affect colonization, autoagglutination, and serum resistance.
Authors: Authors: Chiang SL, Taylor RK, Koomey M, Mekalanos JJ.
Mol Microbiol
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Mol Microbiol
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Live attenuated vaccine vectors.
Constitutive sensory transduction mutations in the Bordetella pertussis bvgS gene.
Authors: Authors: Miller JF, Johnson SA, Black WJ, Beattie DT, Mekalanos JJ, Falkow S.
J Bacteriol
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J Bacteriol
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Salmonella vaccines with mutations in the phoP virulence regulon.
Evidence that glutamic acid 167 is an active-site residue of Shiga-like toxin I.
Authors: Authors: Hovde CJ, Calderwood SB, Mekalanos JJ, Collier RJ.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Identification of a pilus colonization factor that is coordinately regulated with cholera toxin.
Authors: Authors: Taylor RK, Miller VL, Furlong DB, Mekalanos JJ.
Ann Sclavo Collana Monogr
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Ann Sclavo Collana Monogr
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Enzymic activity of cholera toxin. I. New method of assay and the mechanism of ADP-ribosyl transfer.