Jon Clardy, PhD

Hsien Wu and Daisy Yen Wu Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Synthesis and in vitro DMPK profiling of a 1,2-dioxolane-based library with activity against Plasmodium falciparum.
Authors: Authors: Martyn DC, Beletsky G, Cortese JF, Tyndall E, Liu H, Fitzgerald MM, O'Shea TJ, Liang B, Clardy J.
Bioorg Med Chem Lett
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Synthesis of spiro-1,2-dioxolanes and their activity against Plasmodium falciparum.
Authors: Authors: Martyn DC, Ramirez AP, Beattie MJ, Cortese JF, Patel V, Rush MA, Woerpel KA, Clardy J.
Bioorg Med Chem Lett
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Cyclic AMP directly activates NasP, an N-acyl amino acid antibiotic biosynthetic enzyme cloned from an uncultured beta-proteobacterium.
Authors: Authors: Clardy J, Brady SF.
J Bacteriol
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Structure of Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor.
Authors: Authors: Hurt DE, Widom J, Clardy J.
Acta Crystallogr D Biol Crystallogr
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Berkeleydione and berkeleytrione, new bioactive metabolites from an acid mine organism.
Authors: Authors: Stierle DB, Stierle AA, Hobbs JD, Stokken J, Clardy J.
Org Lett
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Relative and absolute stereochemistry of the didemnaketals, metabolites of a Palauan ascidian, Didemnum sp.
Authors: Authors: Salomon CE, Williams DH, Lobkovsky E, Clardy JC, Faulkner DJ.
Org Lett
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CR377, a new pentaketide antifungal agent isolated from an endophytic fungus.
Authors: Authors: Brady SF, Clardy J.
J Nat Prod
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Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution.
Authors: Authors: Liang J, Choi J, Clardy J.
Acta Crystallogr D Biol Crystallogr
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A cholesteryl ester transfer protein inhibitor from an insect-associated fungus.
Authors: Authors: Lee JC, Coval SJ, Clardy J.
J Antibiot (Tokyo)
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Structural studies of complexed FK-506 binding protein.
Authors: Authors: Clardy J.
Ann N Y Acad Sci
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