Jon Clardy, PhD

Hsien Wu and Daisy Yen Wu Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
The natural history of antibiotics.
Authors: Authors: Clardy J, Fischbach MA, Currie CR.
Curr Biol
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FOXO3a mediates the cytotoxic effects of cisplatin in colon cancer cells.
Authors: Authors: Fernández de Mattos S, Villalonga P, Clardy J, Lam EW.

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High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity.
Authors: Authors: Martyn DC, Jones DC, Fairlamb AH, Clardy J.
Bioorg Med Chem Lett
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Cloning and heterologous expression of isocyanide biosynthetic genes from environmental DNA.
Authors: Authors: Brady SF, Clardy J.
Angew Chem Int Ed Engl
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The crystal structure of palmitoyl protein thioesterase-2 (PPT2) reveals the basis for divergent substrate specificities of the two lysosomal thioesterases, PPT1 and PPT2.
Authors: Authors: Calero G, Gupta P, Nonato MC, Tandel S, Biehl ER, Hofmann SL, Clardy J.
J Biol Chem
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Crystal structure of the N-terminal segment of human eukaryotic translation initiation factor 2alpha.
Authors: Authors: Nonato MC, Widom J, Clardy J.
J Biol Chem
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The crystal structure of palmitoyl protein thioesterase 1 and the molecular basis of infantile neuronal ceroid lipofuscinosis.
Authors: Authors: Bellizzi JJ, Widom J, Kemp C, Lu JY, Das AK, Hofmann SL, Clardy J.
Proc Natl Acad Sci U S A
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Megathyrin B: a cytotoxic diterpene from Isodon megathyrsus.
Authors: Authors: Qiu SX, Sun HD, Lobkovsky E, Chai H, Clardy J, Farnsworth NR, Pezzuto JM, Fong HH.
Planta Med
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Structure of the spiroketal-macrolide ossamycin.
Authors: Authors: Kirst HA, Mynderse JS, Martin JW, Baker PJ, Paschal JW, Rios Steiner JL, Lobkovsky E, Clardy J.
J Antibiot (Tokyo)
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Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex.
Authors: Authors: Van Duyne GD, Standaert RF, Karplus PA, Schreiber SL, Clardy J.
Science
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