Jon Clardy, PhD

Hsien Wu and Daisy Yen Wu Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Natural products: Beyond grind and find.
Authors: Authors: Miller SJ, Clardy J.
Nat Chem
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Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.
Authors: Authors: Patel V, Booker M, Kramer M, Ross L, Celatka CA, Kennedy LM, Dvorin JD, Duraisingh MT, Sliz P, Wirth DF, Clardy J.
J Biol Chem
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The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis.
Authors: Authors: Butcher RA, Schroeder FC, Fischbach MA, Straight PD, Kolter R, Walsh CT, Clardy J.
Proc Natl Acad Sci U S A
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Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase.
Authors: Authors: Hurt DE, Sutton AE, Clardy J.
Bioorg Med Chem Lett
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A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells.
Authors: Authors: Kau TR, Schroeder F, Ramaswamy S, Wojciechowski CL, Zhao JJ, Roberts TM, Clardy J, Sellers WR, Silver PA.
Cancer Cell
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Akanthomycin, a new antibiotic pyridone from the entomopathogenic fungus Akanthomyces gracilis.
Authors: Authors: Wagenaar MM, Gibson DM, Clardy J.
Org Lett
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Structural basis for the insensitivity of a serine enzyme (palmitoyl-protein thioesterase) to phenylmethylsulfonyl fluoride.
Authors: Authors: Das AK, Bellizzi JJ, Tandel S, Biehl E, Clardy J, Hofmann SL.
J Biol Chem
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Crystallization and preliminary X-ray crystallographic analysis of the Pseudomonas aeruginosa cyclohexadienyl dehydratase.
Authors: Authors: Kongsaeree P, Liang J, Jensen RA, Clardy J.
Acta Crystallogr D Biol Crystallogr
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Comparison of the structures of the cyclotheonamide A complexes of human alpha-thrombin and bovine beta-trypsin.
Authors: Authors: Ganesh V, Lee AY, Clardy J, Tulinsky A.
Protein Sci
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A pentahalogenated monoterpene from the red alga Portieria hornemannii produces a novel cytotoxicity profile against a diverse panel of human tumor cell lines.
Authors: Authors: Fuller RW, Cardellina JH, Kato Y, Brinen LS, Clardy J, Snader KM, Boyd MR.
J Med Chem
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