Jon Clardy, PhD

Hsien Wu and Daisy Yen Wu Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Identification of protein kinase C activation as a novel mechanism for RGS2 protein upregulation through phenotypic screening of natural product extracts.
Authors: Authors: Raveh A, Schultz PJ, Aschermann L, Carpenter C, Tamayo-Castillo G, Cao S, Clardy J, Neubig RR, Sherman DH, Sjögren B.
Mol Pharmacol
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X-ray crystallography: One size fits most.
Authors: Authors: Stallforth P, Clardy J.
Nature
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Small molecule perimeter defense in entomopathogenic bacteria.
Authors: Authors: Crawford JM, Portmann C, Zhang X, Roeffaers MB, Clardy J.
Proc Natl Acad Sci U S A
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Structure and biosynthesis of amychelin, an unusual mixed-ligand siderophore from Amycolatopsis sp. AA4.
Authors: Authors: Seyedsayamdost MR, Traxler MF, Zheng SL, Kolter R, Clardy J.
J Am Chem Soc
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A concise silylamine approach to 2-amino-3-hydroxy-indoles with potent in vivo antimalaria activity.
Authors: Authors: Urgaonkar S, Cortese JF, Barker RH, Cromwell M, Serrano AE, Wirth DF, Clardy J, Mazitschek R.
Org Lett
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Antiplasmodial activity of piperazine sulfonamides.
Authors: Authors: Martyn DC, Cortese JF, Tyndall E, Dick J, Mazitschek R, Munoz B, Clardy J.
Bioorg Med Chem Lett
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Biosynthesis of the Caenorhabditis elegans dauer pheromone.
Authors: Authors: Butcher RA, Ragains JR, Li W, Ruvkun G, Clardy J, Mak HY.
Proc Natl Acad Sci U S A
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Detecting binding interactions using microarrays of natural product extracts.
Authors: Authors: Schmitz K, Haggarty SJ, McPherson OM, Clardy J, Koehler AN.
J Am Chem Soc
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Bisandrographolide from Andrographis paniculata activates TRPV4 channels.
Authors: Authors: Smith PL, Maloney KN, Pothen RG, Clardy J, Clapham DE.
J Biol Chem
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Palmitoylputrescine, an antibiotic isolated from the heterologous expression of DNA extracted from bromeliad tank water.
Authors: Authors: Brady SF, Clardy J.
J Nat Prod
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