Jon Clardy

Jon Clardy, PhD

Hsien Wu and Daisy Yen Wu Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School

Publications

A symbiotic bacterium of shipworms produces a compound with broad spectrum anti-apicomplexan activity.

Authors: Authors: O'Connor RM, Nepveux V FJ, Abenoja J, Bowden G, Reis P, Beaushaw J, Bone Relat RM, Driskell I, Gimenez F, Riggs MW, Schaefer DA, Schmidt EW, Lin Z, Distel DL, Clardy J, Ramadhar TR, Allred DR, Fritz HM, Rathod P, Chery L, White J.
PLoS Pathog 2020-05-01
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A plant-responsive bacterial-signaling system senses an ethanolamine derivative.

Authors: Authors: Coutinho BG, Mevers E, Schaefer AL, Pelletier DA, Harwood CS, Clardy J, Greenberg EP.
Proc Natl Acad Sci U S A 2018-09-25
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The Crystalline Sponge Method: A Solvent-Based Strategy to Facilitate Noncovalent Ordered Trapping of Solid and Liquid Organic Compounds.

Authors: Authors: Ramadhar TR, Zheng SL, Chen YS, Clardy J.
CrystEngComm 2017-08-21
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Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine.

Authors: Authors: Briggs KJ, Koivunen P, Cao S, Backus KM, Olenchock BA, Patel H, Zhang Q, Signoretti S, Gerfen GJ, Richardson AL, Witkiewicz AK, Cravatt BF, Clardy J, Kaelin WG.
Cell 2016-06-30
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Small-Molecule Reactivation of Mutant p53 to Wild-Type-like p53 through the p53-Hsp40 Regulatory Axis.

Authors: Authors: Hiraki M, Hwang SY, Cao S, Ramadhar TR, Byun S, Yoon KW, Lee JH, Chu K, Gurkar AU, Kolev V, Zhang J, Namba T, Murphy ME, Newman DJ, Mandinova A, Clardy J, Lee SW.
Chem Biol 2015-09-17
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Synthesis of the rosette-inducing factor RIF-1 and analogs.

Authors: Authors: Beemelmanns C, Woznica A, Alegado RA, Cantley AM, King N, Clardy J.
J Am Chem Soc 2014-07-23
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Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.

Authors: Authors: Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, Dorrestein PC, Entian KD, Fischbach MA, Garavelli JS, Göransson U, Gruber CW, Haft DH, Hemscheidt TK, Hertweck C, Hill C, Horswill AR, Jaspars M, Kelly WL, Klinman JP, Kuipers OP, Link AJ, Liu W, Marahiel MA, Mitchell DA, Moll GN, Moore BS, Müller R, Nair SK, Nes IF, Norris GE, Olivera BM, Onaka H, Patchett ML, Piel J, Reaney MJ, Rebuffat S, Ross RP, Sahl HG, Schmidt EW, Selsted ME, Severinov K, Shen B, Sivonen K, Smith L, Stein T, Süssmuth RD, Tagg JR, Tang GL, Truman AW, Vederas JC, Walsh CT, Walton JD, Wenzel SC, Willey JM, van der Donk WA.
Nat Prod Rep 2013-01-01
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Microbial genome mining answers longstanding biosynthetic questions.

Authors: Authors: Crawford JM, Clardy J.
Proc Natl Acad Sci U S A 2012-05-15
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New naphthoquinones and a new d-lactone produced by endophytic fungi from Costa Rica.

Authors: Authors: Cao S, Clardy J.
Tetrahedron Lett 2011-04-27
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Common biosynthetic origins for polycyclic tetramate macrolactams from phylogenetically diverse bacteria.

Authors: Authors: Blodgett JA, Oh DC, Cao S, Currie CR, Kolter R, Clardy J.
Proc Natl Acad Sci U S A 2010-06-29
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