Jon Clardy, PhD

Hsien Wu and Daisy Yen Wu Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
New naphthoquinones and a new d-lactone produced by endophytic fungi from Costa Rica.
Authors: Authors: Cao S, Clardy J.
Tetrahedron Lett
View full abstract on Pubmed
Common biosynthetic origins for polycyclic tetramate macrolactams from phylogenetically diverse bacteria.
Authors: Authors: Blodgett JA, Oh DC, Cao S, Currie CR, Kolter R, Clardy J.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Synthesis and in vitro DMPK profiling of a 1,2-dioxolane-based library with activity against Plasmodium falciparum.
Authors: Authors: Martyn DC, Beletsky G, Cortese JF, Tyndall E, Liu H, Fitzgerald MM, O'Shea TJ, Liang B, Clardy J.
Bioorg Med Chem Lett
View full abstract on Pubmed
Synthesis of spiro-1,2-dioxolanes and their activity against Plasmodium falciparum.
Authors: Authors: Martyn DC, Ramirez AP, Beattie MJ, Cortese JF, Patel V, Rush MA, Woerpel KA, Clardy J.
Bioorg Med Chem Lett
View full abstract on Pubmed
Cyclic AMP directly activates NasP, an N-acyl amino acid antibiotic biosynthetic enzyme cloned from an uncultured beta-proteobacterium.
Authors: Authors: Clardy J, Brady SF.
J Bacteriol
View full abstract on Pubmed
Structure of Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor.
Authors: Authors: Hurt DE, Widom J, Clardy J.
Acta Crystallogr D Biol Crystallogr
View full abstract on Pubmed
Berkeleydione and berkeleytrione, new bioactive metabolites from an acid mine organism.
Authors: Authors: Stierle DB, Stierle AA, Hobbs JD, Stokken J, Clardy J.
Org Lett
View full abstract on Pubmed
Relative and absolute stereochemistry of the didemnaketals, metabolites of a Palauan ascidian, Didemnum sp.
Authors: Authors: Salomon CE, Williams DH, Lobkovsky E, Clardy JC, Faulkner DJ.
Org Lett
View full abstract on Pubmed
CR377, a new pentaketide antifungal agent isolated from an endophytic fungus.
Authors: Authors: Brady SF, Clardy J.
J Nat Prod
View full abstract on Pubmed
Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution.
Authors: Authors: Liang J, Choi J, Clardy J.
Acta Crystallogr D Biol Crystallogr
View full abstract on Pubmed