Jon Clardy, PhD

Hsien Wu and Daisy Yen Wu Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Selection for high oridonin yield in the Chinese medicinal plant Isodon (Lamiaceae) using a combined phylogenetics and population genetics approach.
Authors: Authors: Harris ES, Cao S, Schoville SD, Dong C, Wang W, Jian Z, Zhao Z, Eisenberg DM, Clardy J.
PLoS One
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Inhibition of tumor cells interacting with stromal cells by xanthones isolated from a Costa Rican Penicillium sp.
Authors: Authors: Cao S, McMillin DW, Tamayo G, Delmore J, Mitsiades CS, Clardy J.
J Nat Prod
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Traditional Medicine Collection Tracking System (TM-CTS): a database for ethnobotanically driven drug-discovery programs.
Authors: Authors: Harris ES, Erickson SD, Tolopko AN, Cao S, Craycroft JA, Scholten R, Fu Y, Wang W, Liu Y, Zhao Z, Clardy J, Shamu CE, Eisenberg DM.
J Ethnopharmacol
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Dapdiamides, tripeptide antibiotics formed by unconventional amide ligases.
Authors: Authors: Dawlaty J, Zhang X, Fischbach MA, Clardy J.
J Nat Prod
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Natural products: Beyond grind and find.
Authors: Authors: Miller SJ, Clardy J.
Nat Chem
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Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.
Authors: Authors: Patel V, Booker M, Kramer M, Ross L, Celatka CA, Kennedy LM, Dvorin JD, Duraisingh MT, Sliz P, Wirth DF, Clardy J.
J Biol Chem
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The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis.
Authors: Authors: Butcher RA, Schroeder FC, Fischbach MA, Straight PD, Kolter R, Walsh CT, Clardy J.
Proc Natl Acad Sci U S A
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Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase.
Authors: Authors: Hurt DE, Sutton AE, Clardy J.
Bioorg Med Chem Lett
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A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells.
Authors: Authors: Kau TR, Schroeder F, Ramaswamy S, Wojciechowski CL, Zhao JJ, Roberts TM, Clardy J, Sellers WR, Silver PA.
Cancer Cell
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Akanthomycin, a new antibiotic pyridone from the entomopathogenic fungus Akanthomyces gracilis.
Authors: Authors: Wagenaar MM, Gibson DM, Clardy J.
Org Lett
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