Jon Clardy, PhD

Hsien Wu and Daisy Yen Wu Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Discovery of Dual-Stage Malaria Inhibitors with New Targets.
Authors: Authors: Raphemot R, Lafuente-Monasterio MJ, Gamo-Benito FJ, Clardy J, Derbyshire ER.
Antimicrob Agents Chemother
View full abstract on Pubmed
Hybrid biosynthesis of roseobacticides from algal and bacterial precursor molecules.
Authors: Authors: Seyedsayamdost MR, Wang R, Kolter R, Clardy J.
J Am Chem Soc
View full abstract on Pubmed
A sexually conditioned switch of chemosensory behavior in C. elegans.
Authors: Authors: Sakai N, Iwata R, Yokoi S, Butcher RA, Clardy J, Tomioka M, Iino Y.
PLoS One
View full abstract on Pubmed
Phenolic compounds as antiangiogenic CMG2 inhibitors from Costa Rican endophytic fungi.
Authors: Authors: Cao S, Cryan L, Habeshian KA, Murillo C, Tamayo-Castillo G, Rogers MS, Clardy J.
Bioorg Med Chem Lett
View full abstract on Pubmed
The next opportunity in anti-malaria drug discovery: the liver stage.
Authors: Authors: Derbyshire ER, Mota MM, Clardy J.
PLoS Pathog
View full abstract on Pubmed
Asterogynins: secondary metabolites from a Costa Rican endophytic fungus.
Authors: Authors: Cao S, Ross L, Tamayo G, Clardy J.
Org Lett
View full abstract on Pubmed
Bionectriol A, a polyketide glycoside from the fungus Bionectria sp. associated with the fungus-growing ant, Apterostigma dentigerum.
Authors: Authors: Freinkman E, Oh DC, Scott JJ, Currie CR, Clardy J.
Tetrahedron Lett
View full abstract on Pubmed
Progestins activate the AKT pathway in leiomyoma cells and promote survival.
Authors: Authors: Hoekstra AV, Sefton EC, Berry E, Lu Z, Hardt J, Marsh E, Yin P, Clardy J, Chakravarti D, Bulun S, Kim JJ.
J Clin Endocrinol Metab
View full abstract on Pubmed
The evolution of gene collectives: How natural selection drives chemical innovation.
Authors: Authors: Fischbach MA, Walsh CT, Clardy J.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
FeeM, an N-acyl amino acid synthase from an uncultured soil microbe: structure, mechanism, and acyl carrier protein binding.
Authors: Authors: Van Wagoner RM, Clardy J.
Structure
View full abstract on Pubmed