Jon Clardy, PhD

Hsien Wu and Daisy Yen Wu Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
A new antibacterial octaketide and cytotoxic phenylethanoid glycosides from Pogostemon cablin (Blanco) Benth.
Authors: Authors: Kim KH, Beemelmanns C, Clardy J, Cao S.
Bioorg Med Chem Lett
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Bacterial symbionts in agricultural systems provide a strategic source for antibiotic discovery.
Authors: Authors: Ramadhar TR, Beemelmanns C, Currie CR, Clardy J.
J Antibiot (Tokyo)
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Protein evolution: when two become three.
Authors: Authors: Stallforth P, Clardy J.
Curr Biol
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Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors.
Authors: Authors: Dong CK, Urgaonkar S, Cortese JF, Gamo FJ, Garcia-Bustos JF, Lafuente MJ, Patel V, Ross L, Coleman BI, Derbyshire ER, Clish CB, Serrano AE, Cromwell M, Barker RH, Dvorin JD, Duraisingh MT, Wirth DF, Clardy J, Mazitschek R.
Chem Biol
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Sceliphrolactam, a polyene macrocyclic lactam from a wasp-associated Streptomyces sp.
Authors: Authors: Oh DC, Poulsen M, Currie CR, Clardy J.
Org Lett
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A non-radioactive DAPI-based high-throughput in vitro assay to assess Plasmodium falciparum responsiveness to antimalarials--increased sensitivity of P. falciparum to chloroquine in Senegal.
Authors: Authors: Ndiaye D, Patel V, Demas A, LeRoux M, Ndir O, Mboup S, Clardy J, Lakshmanan V, Daily JP, Wirth DF.
Am J Trop Med Hyg
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Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum.
Authors: Authors: Patel V, Mazitschek R, Coleman B, Nguyen C, Urgaonkar S, Cortese J, Barker RH, Greenberg E, Tang W, Bradner JE, Schreiber SL, Duraisingh MT, Wirth DF, Clardy J.
J Med Chem
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Codinaeopsin, an antimalarial fungal polyketide.
Authors: Authors: Kontnik R, Clardy J.
Org Lett
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High-throughput Plasmodium falciparum growth assay for malaria drug discovery.
Authors: Authors: Baniecki ML, Wirth DF, Clardy J.
Antimicrob Agents Chemother
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Total synthesis of psammaplysenes A and B, naturally occurring inhibitors of FOXO1a nuclear export.
Authors: Authors: Georgiades SN, Clardy J.
Org Lett
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