Luk Vandenberghe, PhD

Associate Professor of Ophthalmology, Massachusetts Eye and Ear Infirmary
Immunogenicity of an AAV-based, room-temperature stable, single dose COVID-19 vaccine in mice and non-human primates.
Authors: Authors: Zabaleta N, Dai W, Bhatt U, Chichester JA, Sanmiguel J, Estelien R, Michalson KT, Diop C, Maciorowski D, Qi W, Hudspeth E, Cucalon A, Dyer CD, Pampena MB, Knox JJ, LaRocque RC, Charles RC, Li D, Kim M, Sheridan A, Storm N, Johnson RI, Feldman J, Hauser BM, Zinn E, Ryan A, Kobayashi DT, Chauhan R, McGlynn M, Ryan ET, Schmidt AG, Price B, Honko A, Griffiths A, Yaghmour S, Hodge R, Betts MR, Freeman MW, Wilson JM, Vandenberghe LH.
bioRxiv
View full abstract on Pubmed
Novel engineered, membrane-localized variants of vascular endothelial growth factor (VEGF) protect retinal ganglion cells: a proof-of-concept study.
Authors: Authors: Shen J, Xiao R, Bair J, Wang F, Vandenberghe LH, Dartt D, Baranov P, Ng YSE.
Cell Death Dis
View full abstract on Pubmed
Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c.
Authors: Authors: Pan B, Askew C, Galvin A, Heman-Ackah S, Asai Y, Indzhykulian AA, Jodelka FM, Hastings ML, Lentz JJ, Vandenberghe LH, Holt JR, Géléoc GS.
Nat Biotechnol
View full abstract on Pubmed
Retinal gene therapy coming of age.
Authors: Authors: Cepko CL, Vandenberghe LH.
Hum Gene Ther
View full abstract on Pubmed
Naturally occurring singleton residues in AAV capsid impact vector performance and illustrate structural constraints.
Authors: Authors: Vandenberghe LH, Breous E, Nam HJ, Gao G, Xiao R, Sandhu A, Johnston J, Debyser Z, Agbandje-McKenna M, Wilson JM.
Gene Ther
View full abstract on Pubmed
AAV as an immunogen.
Authors: Authors: Vandenberghe LH, Wilson JM.
Curr Gene Ther
View full abstract on Pubmed
Homologous Recombination Offers Advantages over Transposition-Based Systems to Generate Recombinant Baculovirus for Adeno-Associated Viral Vector Production.
Authors: Authors: Jacob A, Brun L, Jiménez Gil P, Ménard L, Bouzelha M, Broucque F, Roblin A, Vandenberghe LH, Adjali O, Robin C, François A, Blouin V, Penaud-Budloo M, Ayuso E.
Biotechnol J
View full abstract on Pubmed
Breaking and Sealing Barriers in Retinal Gene Therapy.
Authors: Authors: Miller JW, Vandenberghe LH.
Mol Ther
View full abstract on Pubmed
In vitro and in vivo rescue of aberrant splicing in CEP290-associated LCA by antisense oligonucleotide delivery.
Authors: Authors: Garanto A, Chung DC, Duijkers L, Corral-Serrano JC, Messchaert M, Xiao R, Bennett J, Vandenberghe LH, Collin RW.
Hum Mol Genet
View full abstract on Pubmed
AAV9 targets cone photoreceptors in the nonhuman primate retina.
Authors: Authors: Vandenberghe LH, Bell P, Maguire AM, Xiao R, Hopkins TB, Grant R, Bennett J, Wilson JM.
PLoS One
View full abstract on Pubmed