Luk Vandenberghe, PhD

Associate Professor of Ophthalmology, Massachusetts Eye and Ear Infirmary
Homologous Recombination Offers Advantages over Transposition-Based Systems to Generate Recombinant Baculovirus for Adeno-Associated Viral Vector Production.
Authors: Authors: Jacob A, Brun L, Jiménez Gil P, Ménard L, Bouzelha M, Broucque F, Roblin A, Vandenberghe LH, Adjali O, Robin C, François A, Blouin V, Penaud-Budloo M, Ayuso E.
Biotechnol J
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Breaking and Sealing Barriers in Retinal Gene Therapy.
Authors: Authors: Miller JW, Vandenberghe LH.
Mol Ther
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In vitro and in vivo rescue of aberrant splicing in CEP290-associated LCA by antisense oligonucleotide delivery.
Authors: Authors: Garanto A, Chung DC, Duijkers L, Corral-Serrano JC, Messchaert M, Xiao R, Bennett J, Vandenberghe LH, Collin RW.
Hum Mol Genet
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AAV9 targets cone photoreceptors in the nonhuman primate retina.
Authors: Authors: Vandenberghe LH, Bell P, Maguire AM, Xiao R, Hopkins TB, Grant R, Bennett J, Wilson JM.
PLoS One
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The pleiotropic effects of natural AAV infections on liver-directed gene transfer in macaques.
Authors: Authors: Wang L, Calcedo R, Wang H, Bell P, Grant R, Vandenberghe LH, Sanmiguel J, Morizono H, Batshaw ML, Wilson JM.
Mol Ther
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Novel adeno-associated virus serotypes efficiently transduce murine photoreceptors.
Authors: Authors: Allocca M, Mussolino C, Garcia-Hoyos M, Sanges D, Iodice C, Petrillo M, Vandenberghe LH, Wilson JM, Marigo V, Surace EM, Auricchio A.
J Virol
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Gene Therapy Preserves Retinal Structure and Function in a Mouse Model of NMNAT1-Associated Retinal Degeneration.
Authors: Authors: Greenwald SH, Brown EE, Scandura MJ, Hennessey E, Farmer R, Pawlyk BS, Xiao R, Vandenberghe LH, Pierce EA.
Mol Ther Methods Clin Dev
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Efficient Gene Transfer to the Central Nervous System by Single-Stranded Anc80L65.
Authors: Authors: Hudry E, Andres-Mateos E, Lerner EP, Volak A, Cohen O, Hyman BT, Maguire CA, Vandenberghe LH.
Mol Ther Methods Clin Dev
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Understanding Cone Photoreceptor Cell Death in Achromatopsia.
Authors: Authors: Carvalho LS, Vandenberghe LH.
Adv Exp Med Biol
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Adeno-associated viruses as liver-directed gene delivery vehicles: focus on lipoprotein metabolism.
Authors: Authors: Lagor WR, Johnston JC, Lock M, Vandenberghe LH, Rader DJ.
Methods Mol Biol
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