Luk Vandenberghe, PhD

Associate Professor of Ophthalmology, Massachusetts Eye and Ear Infirmary
In vivo gene editing in dystrophic mouse muscle and muscle stem cells.
Authors: Authors: Tabebordbar M, Zhu K, Cheng JKW, Chew WL, Widrick JJ, Yan WX, Maesner C, Wu EY, Xiao R, Ran FA, Cong L, Zhang F, Vandenberghe LH, Church GM, Wagers AJ.
Science
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Influence of serotype, cell type, tissue composition, and time after inoculation on gene expression in recombinant adeno-associated viral vector-transduced equine joint tissues.
Authors: Authors: Mason JB, Vandenberghe LH, Xiao R, Wilson JM, Richardson DW.
Am J Vet Res
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Adeno-associated virus-mediated gene transfer to nonhuman primate liver can elicit destructive transgene-specific T cell responses.
Authors: Authors: Gao G, Wang Q, Calcedo R, Mays L, Bell P, Wang L, Vandenberghe LH, Grant R, Sanmiguel J, Furth EE, Wilson JM.
Hum Gene Ther
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Heparin binding directs activation of T cells against adeno-associated virus serotype 2 capsid.
Authors: Authors: Vandenberghe LH, Wang L, Somanathan S, Zhi Y, Figueredo J, Calcedo R, Sanmiguel J, Desai RA, Chen CS, Johnston J, Grant RL, Gao G, Wilson JM.
Nat Med
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Hair Cell Transduction Efficiency of Single- and Dual-AAV Serotypes in Adult Murine Cochleae.
Authors: Authors: Omichi R, Yoshimura H, Shibata SB, Vandenberghe LH, Smith RJH.
Mol Ther Methods Clin Dev
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Synthetic Adeno-Associated Viral Vector Efficiently Targets Mouse and Nonhuman Primate Retina In Vivo.
Authors: Authors: Carvalho LS, Xiao R, Wassmer SJ, Langsdorf A, Zinn E, Pacouret S, Shah S, Comander JI, Kim LA, Lim L, Vandenberghe LH.
Hum Gene Ther
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In Silico Reconstruction of the Viral Evolutionary Lineage Yields a Potent Gene Therapy Vector.
Authors: Authors: Zinn E, Pacouret S, Khaychuk V, Turunen HT, Carvalho LS, Andres-Mateos E, Shah S, Shelke R, Maurer AC, Plovie E, Xiao R, Vandenberghe LH.
Cell Rep
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Novel adeno-associated viral vectors for retinal gene therapy.
Authors: Authors: Vandenberghe LH, Auricchio A.
Gene Ther
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Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver.
Authors: Authors: Breous E, Somanathan S, Vandenberghe LH, Wilson JM.
Hepatology
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New recombinant serotypes of AAV vectors.
Authors: Authors: Gao G, Vandenberghe LH, Wilson JM.
Curr Gene Ther
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