Marc Kirschner, PhD

John Franklin Enders University Professor of Systems Biology, Harvard Medical School
Conservation of microtubule associated proteins. Isolation and characterization of tau and the high molecular weight microtubule associated protein from chicken brain and from mouse fibroblasts and comparison to the corresponding mammalian brain proteins.
Authors: Authors: Cleveland DW, Spiegelman BM, Kirschner MW.
J Biol Chem
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Tubulin requires tau for growth onto microtubule initiating sites.
Authors: Authors: Witman GB, Cleveland DW, Weingarten MD, Kirschner MW.
Proc Natl Acad Sci U S A
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Proteomic and Metabolomic Characterization of a Mammalian Cellular Transition from Quiescence to Proliferation.
Authors: Authors: Lee HJ, Jedrychowski MP, Vinayagam A, Wu N, Shyh-Chang N, Hu Y, Min-Wen C, Moore JK, Asara JM, Lyssiotis CA, Perrimon N, Gygi SP, Cantley LC, Kirschner MW.
Cell Rep
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Substrate degradation by the proteasome: a single-molecule kinetic analysis.
Authors: Authors: Lu Y, Lee BH, King RW, Finley D, Kirschner MW.
Science
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Beyond Darwin: evolvability and the generation of novelty.
Authors: Authors: Kirschner M.
BMC Biol
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Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation.
Authors: Authors: Jain M, Nilsson R, Sharma S, Madhusudhan N, Kitami T, Souza AL, Kafri R, Kirschner MW, Clish CB, Mootha VK.
Science
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Using buoyant mass to measure the growth of single cells.
Authors: Authors: Godin M, Delgado FF, Son S, Grover WH, Bryan AK, Tzur A, Jorgensen P, Payer K, Grossman AD, Kirschner MW, Manalis SR.
Nat Methods
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Different phosphorylation states of the anaphase promoting complex in response to antimitotic drugs: a quantitative proteomic analysis.
Authors: Authors: Steen JA, Steen H, Georgi A, Parker K, Springer M, Kirchner M, Hamprecht F, Kirschner MW.
Proc Natl Acad Sci U S A
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Characterization of a new qQq-FTICR mass spectrometer for post-translational modification analysis and top-down tandem mass spectrometry of whole proteins.
Authors: Authors: Jebanathirajah JA, Pittman JL, Thomson BA, Budnik BA, Kaur P, Rape M, Kirschner M, Costello CE, O'Connor PB.
J Am Soc Mass Spectrom
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Purification and architecture of the ubiquitous Wave complex.
Authors: Authors: Gautreau A, Ho HY, Li J, Steen H, Gygi SP, Kirschner MW.
Proc Natl Acad Sci U S A
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