Marc Kirschner

Marc Kirschner, PhD

John Franklin Enders University Professor of Systems Biology, Harvard Medical School

Publications

Cell size sensing in animal cells coordinates anabolic growth rates and cell cycle progression to maintain cell size uniformity.

Authors: Authors: Ginzberg MB, Chang N, D'Souza H, Patel N, Kafri R, Kirschner MW.
Elife 2018-06-11
View full abstract on Pubmed

Correction: Dorsoventral Patterning in Hemichordates: Insights into Early Chordate Evolution.

Authors: Authors: Lowe CJ, Terasaki M, Wu M, Freeman RM, Runft L, Kwan K, Haigo S, Aronowicz J, Lander E, Gruber C, Smith M, Kirschner M, Gerhart J.
PLoS Biol 2015-12-01
View full abstract on Pubmed

Deep proteomics of the Xenopus laevis egg using an mRNA-derived reference database.

Authors: Authors: Wühr M, Freeman RM, Presler M, Horb ME, Peshkin L, Gygi S, Kirschner MW.
Curr Biol 2014-07-07
View full abstract on Pubmed

Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation.

Authors: Authors: Xie Y, Avello M, Schirle M, McWhinnie E, Feng Y, Bric-Furlong E, Wilson C, Nathans R, Zhang J, Kirschner MW, Huang SM, Cong F.
J Biol Chem 2013-02-01
View full abstract on Pubmed

Thiostrepton and derivatives exhibit antimalarial and gametocytocidal activity by dually targeting parasite proteasome and apicoplast.

Authors: Authors: Aminake MN, Schoof S, Sologub L, Leubner M, Kirschner M, Arndt HD, Pradel G.
Antimicrob Agents Chemother 2011-04-01
View full abstract on Pubmed

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.

Authors: Authors: Huang SM, Mishina YM, Liu S, Cheung A, Stegmeier F, Michaud GA, Charlat O, Wiellette E, Zhang Y, Wiessner S, Hild M, Shi X, Wilson CJ, Mickanin C, Myer V, Fazal A, Tomlinson R, Serluca F, Shao W, Cheng H, Shultz M, Rau C, Schirle M, Schlegl J, Ghidelli S, Fawell S, Lu C, Curtis D, Kirschner MW, Lengauer C, Finan PM, Tallarico JA, Bouwmeester T, Porter JA, Bauer A, Cong F.
Nature 2009-10-01
View full abstract on Pubmed

Obituary: Reinhart Heinrich (1946-2006).

Authors: Authors: Kirschner MW.
Nature 2006-12-07
View full abstract on Pubmed

Stable isotope-free relative and absolute quantitation of protein phosphorylation stoichiometry by MS.

Authors: Authors: Steen H, Jebanathirajah JA, Springer M, Kirschner MW.
Proc Natl Acad Sci U S A 2005-03-15
View full abstract on Pubmed

Graded positional information: interpretation for both fate and guidance.

Authors: Authors: Osterfield M, Kirschner MW, Flanagan JG.
Cell 2003-05-16
View full abstract on Pubmed

The anaphase-promoting complex mediates TGF-beta signaling by targeting SnoN for destruction.

Authors: Authors: Wan Y, Liu X, Kirschner MW.
Mol Cell 2001-11-01
View full abstract on Pubmed