Marc Kirschner, PhD
John Franklin Enders University Professor of Systems Biology, Harvard Medical School
Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression.
Authors: Authors: Wu S, Wang W, Kong X, Congdon LM, Yokomori K, Kirschner MW, Rice JC.
Genes Dev
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Genes Dev
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Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways.
Authors: Authors: Gao D, Inuzuka H, Korenjak M, Tseng A, Wu T, Wan L, Kirschner M, Dyson N, Wei W.
Mol Biol Cell
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Mol Biol Cell
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Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components.
Authors: Authors: Peterson JR, Lebensohn AM, Pelish HE, Kirschner MW.
Chem Biol
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Chem Biol
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Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry.
Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC.
Authors: Authors: Ayad NG, Rankin S, Murakami M, Jebanathirajah J, Gygi S, Kirschner MW.
Cell
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Cell
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Molecular targets of vertebrate segmentation: two mechanisms control segmental expression of Xenopus hairy2 during somite formation.
Authors: Authors: Davis RL, Turner DL, Evans LM, Kirschner MW.
Dev Cell
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Dev Cell
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Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts.
Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1.
The role of cyclin-dependent kinase 5 and a novel regulatory subunit in regulating muscle differentiation and patterning.
Authors: Authors: Philpott A, Porro EB, Kirschner MW, Tsai LH.
Genes Dev
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Genes Dev
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In memory of harold weintraub.