Marc Kirschner, PhD
John Franklin Enders University Professor of Systems Biology, Harvard Medical School
Exploiting polypharmacology for drug target deconvolution.
Authors: Authors: Gujral TS, Peshkin L, Kirschner MW.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Direct observation of mammalian cell growth and size regulation.
Authors: Authors: Son S, Tzur A, Weng Y, Jorgensen P, Kim J, Kirschner MW, Manalis SR.
Nat Methods
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Nat Methods
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Self-assembly of filopodia-like structures on supported lipid bilayers.
FLEXIQuant: a novel tool for the absolute quantification of proteins, and the simultaneous identification and quantification of potentially modified peptides.
Authors: Authors: Singh S, Springer M, Steen J, Kirschner MW, Steen H.
J Proteome Res
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J Proteome Res
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The processivity of multiubiquitination by the APC determines the order of substrate degradation.
Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex.
Authors: Authors: Ho HY, Rohatgi R, Lebensohn AM, Li J, Gygi SP, Kirschner MW.
Cell
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Cell
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The secreted Frizzled-related protein Sizzled functions as a negative feedback regulator of extreme ventral mesoderm.
CR16 forms a complex with N-WASP in brain and is a novel member of a conserved proline-rich actin-binding protein family.
Authors: Authors: Ho HY, Rohatgi R, Ma L, Kirschner MW.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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The fate of cells in the tailbud of Xenopus laevis.
Evolvability.