Marc Kirschner, PhD
John Franklin Enders University Professor of Systems Biology, Harvard Medical School
Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis.
Authors: Authors: Weiner OD, Rentel MC, Ott A, Brown GE, Jedrychowski M, Yaffe MB, Gygi SP, Cantley LC, Bourne HR, Kirschner MW.
PLoS Biol
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PLoS Biol
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Targeting cell division: small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality.
Authors: Authors: Margalit DN, Romberg L, Mets RB, Hebert AM, Mitchison TJ, Kirschner MW, RayChaudhuri D.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Mouse ribonucleotide reductase R2 protein: a new target for anaphase-promoting complex-Cdh1-mediated proteolysis.
Authors: Authors: Chabes AL, Pfleger CM, Kirschner MW, Thelander L.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex.
Molecular "vitalism".
Geminin, a neuralizing molecule that demarcates the future neural plate at the onset of gastrulation.
Authors: Authors: Kroll KL, Salic AN, Evans LM, Kirschner MW.
Development
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Development
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Systematic identification of mitotic phosphoproteins.
Authors: Authors: Stukenberg PT, Lustig KD, McGarry TJ, King RW, Kuang J, Kirschner MW.
Curr Biol
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Curr Biol
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Molecular cloning of tyrosine kinases in the early Xenopus embryo: identification of Eck-related genes expressed in cranial neural crest cells of the second (hyoid) arch.
Science and the new administration.
Cyclin is degraded by the ubiquitin pathway.