Marc Kirschner, PhD

John Franklin Enders University Professor of Systems Biology, Harvard Medical School
Thiostrepton and derivatives exhibit antimalarial and gametocytocidal activity by dually targeting parasite proteasome and apicoplast.
Authors: Authors: Aminake MN, Schoof S, Sologub L, Leubner M, Kirschner M, Arndt HD, Pradel G.
Antimicrob Agents Chemother
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Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.
Authors: Authors: Huang SM, Mishina YM, Liu S, Cheung A, Stegmeier F, Michaud GA, Charlat O, Wiellette E, Zhang Y, Wiessner S, Hild M, Shi X, Wilson CJ, Mickanin C, Myer V, Fazal A, Tomlinson R, Serluca F, Shao W, Cheng H, Shultz M, Rau C, Schirle M, Schlegl J, Ghidelli S, Fawell S, Lu C, Curtis D, Kirschner MW, Lengauer C, Finan PM, Tallarico JA, Bouwmeester T, Porter JA, Bauer A, Cong F.
Nature
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Obituary: Reinhart Heinrich (1946-2006).
Authors: Authors: Kirschner MW.
Nature
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Stable isotope-free relative and absolute quantitation of protein phosphorylation stoichiometry by MS.
Authors: Authors: Steen H, Jebanathirajah JA, Springer M, Kirschner MW.
Proc Natl Acad Sci U S A
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Graded positional information: interpretation for both fate and guidance.
Authors: Authors: Osterfield M, Kirschner MW, Flanagan JG.
Cell
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The anaphase-promoting complex mediates TGF-beta signaling by targeting SnoN for destruction.
Authors: Authors: Wan Y, Liu X, Kirschner MW.
Mol Cell
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The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1.
Authors: Authors: Pfleger CM, Kirschner MW.
Genes Dev
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Mitotic inactivation of a human SWI/SNF chromatin remodeling complex.
Authors: Authors: Sif S, Stukenberg PT, Kirschner MW, Kingston RE.
Genes Dev
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Expression cloning in the test tube.
Authors: Authors: King RW, Lustig KD, Stukenberg PT, McGarry TJ, Kirschner MW.
Science
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Early events in DNA replication require cyclin E and are blocked by p21CIP1.
Authors: Authors: Jackson PK, Chevalier S, Philippe M, Kirschner MW.
J Cell Biol
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