Marc Kirschner, PhD
John Franklin Enders University Professor of Systems Biology, Harvard Medical School
Evidence that fold-change, and not absolute level, of beta-catenin dictates Wnt signaling.
The theory of facilitated variation.
The meaning of systems biology.
The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway.
Authors: Authors: Lee E, Salic A, Krüger R, Heinrich R, Kirschner MW.
PLoS Biol
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PLoS Biol
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Cyclin B and E2F-1 expression in prostate carcinoma cells treated with the novel retinoid CD437 are regulated by the ubiquitin-mediated pathway.
Authors: Authors: Farhana L, Dawson M, Rishi AK, Zhang Y, Van Buren E, Trivedi C, Reichert U, Fang G, Kirschner MW, Fontana JA.
Cancer Res
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Cancer Res
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Two tandem verprolin homology domains are necessary for a strong activation of Arp2/3 complex-induced actin polymerization and induction of microspike formation by N-WASP.
Authors: Authors: Yamaguchi H, Miki H, Suetsugu S, Ma L, Kirschner MW, Takenawa T.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Identification of a new uracil-DNA glycosylase family by expression cloning using synthetic inhibitors.
Authors: Authors: Haushalter KA, Todd Stukenberg MW, Kirschner MW, Verdine GL.
Curr Biol
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Curr Biol
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Sizzled: a secreted Xwnt8 antagonist expressed in the ventral marginal zone of Xenopus embryos.
Authors: Authors: Salic AN, Kroll KL, Evans LM, Kirschner MW.
Development
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Development
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Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates.
Mitosis in transition.