Marc Kirschner, PhD
John Franklin Enders University Professor of Systems Biology, Harvard Medical School
The master cell cycle regulator APC-Cdc20 regulates ciliary length and disassembly of the primary cilium.
Profiling of ubiquitin-like modifications reveals features of mitotic control.
Authors: Authors: Merbl Y, Refour P, Patel H, Springer M, Kirschner MW.
Cell
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Cell
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Remodeling of the metabolome during early frog development.
Authors: Authors: Vastag L, Jorgensen P, Peshkin L, Wei R, Rabinowitz JD, Kirschner MW.
PLoS One
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PLoS One
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Activation of the WAVE complex by coincident signals controls actin assembly.
Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation.
Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates.
Anteroposterior patterning in hemichordates and the origins of the chordate nervous system.
Authors: Authors: Lowe CJ, Wu M, Salic A, Evans L, Lander E, Stange-Thomann N, Gruber CE, Gerhart J, Kirschner M.
Cell
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Cell
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Timing of events in mitosis.
Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate.
Quantitative measurement of the catastrophe rate of dynamic microtubules.