Nathanael Gray, PhD
Nancy Lurie Marks Professor of Biological Chemistry and Molecular Pharmacology in the Field of Medical Oncology, Dana-Farber Cancer Institute
JNK2 Is Required for the Tumorigenic Properties of Melanoma Cells.
Authors: Authors: Du L, Anderson A, Nguyen K, Ojeda SS, Ortiz-Rivera I, Nguyen TN, Zhang T, Kaoud TS, Gray NS, Dalby KN, Tsai KY.
ACS Chem Biol
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ACS Chem Biol
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Small-molecule targeting of brachyury transcription factor addiction in chordoma.
Authors: Authors: Sharifnia T, Wawer MJ, Chen T, Huang QY, Weir BA, Sizemore A, Lawlor MA, Goodale A, Cowley GS, Vazquez F, Ott CJ, Francis JM, Sassi S, Cogswell P, Sheppard HE, Zhang T, Gray NS, Clarke PA, Blagg J, Workman P, Sommer J, Hornicek F, Root DE, Hahn WC, Bradner JE, Wong KK, Clemons PA, Lin CY, Kotz JD, Schreiber SL.
Nat Med
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Nat Med
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BMX-Mediated Regulation of Multiple Tyrosine Kinases Contributes to Castration Resistance in Prostate Cancer.
Authors: Authors: Chen S, Cai C, Sowalsky AG, Ye H, Ma F, Yuan X, Simon NI, Gray NS, Balk SP.
Cancer Res
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Cancer Res
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BTKCys481Ser drives ibrutinib resistance via ERK1/2 and protects BTKwild-type MYD88-mutated cells by a paracrine mechanism.
Authors: Authors: Chen JG, Liu X, Munshi M, Xu L, Tsakmaklis N, Demos MG, Kofides A, Guerrera ML, Chan GG, Patterson CJ, Meid K, Gustine J, Dubeau T, Severns P, Castillo JJ, Hunter ZR, Wang J, Buhrlage SJ, Gray NS, Treon SP, Yang G.
Blood
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Blood
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Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression.
Authors: Authors: Rusan M, Li K, Li Y, Christensen CL, Abraham BJ, Kwiatkowski N, Buczkowski KA, Bockorny B, Chen T, Li S, Rhee K, Zhang H, Chen W, Terai H, Tavares T, Leggett AL, Li T, Wang Y, Zhang T, Kim TJ, Hong SH, Poudel-Neupane N, Silkes M, Mudianto T, Tan L, Shimamura T, Meyerson M, Bass AJ, Watanabe H, Gray NS, Young RA, Wong KK, Hammerman PS.
Cancer Discov
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Cancer Discov
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The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists.
Authors: Authors: Vollmer S, Strickson S, Zhang T, Gray N, Lee KL, Rao VR, Cohen P.
Biochem J
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Biochem J
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Structure-guided development of covalent TAK1 inhibitors.
Authors: Authors: Tan L, Gurbani D, Weisberg EL, Hunter JC, Li L, Jones DS, Ficarro SB, Mowafy S, Tam CP, Rao S, Du G, Griffin JD, Sorger PK, Marto JA, Westover KD, Gray NS.
Bioorg Med Chem
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Bioorg Med Chem
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Covalent Targeting of Fibroblast Growth Factor Receptor Inhibits Metastatic Breast Cancer.
Authors: Authors: Brown WS, Tan L, Smith A, Gray NS, Wendt MK.
Mol Cancer Ther
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Mol Cancer Ther
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EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung Cancer.
Authors: Authors: Amato KR, Wang S, Tan L, Hastings AK, Song W, Lovly CM, Meador CB, Ye F, Lu P, Balko JM, Colvin DC, Cates JM, Pao W, Gray NS, Chen J.
Cancer Res
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Cancer Res
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Identification of Novel Small Molecule Inhibitors of Oncogenic RET Kinase.
Authors: Authors: Moccia M, Liu Q, Guida T, Federico G, Brescia A, Zhao Z, Choi HG, Deng X, Tan L, Wang J, Billaud M, Gray NS, Carlomagno F, Santoro M.
PLoS One
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PLoS One
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