Nathanael Gray, PhD

Nancy Lurie Marks Professor of Biological Chemistry and Molecular Pharmacology in the Field of Medical Oncology, Dana-Farber Cancer Institute
Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations.
Authors: Authors: de Wispelaere M, Du G, Donovan KA, Zhang T, Eleuteri NA, Yuan JC, Kalabathula J, Nowak RP, Fischer ES, Gray NS, Yang PL.
Nat Commun
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Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype.
Authors: Authors: Olson CM, Liang Y, Leggett A, Park WD, Li L, Mills CE, Elsarrag SZ, Ficarro SB, Zhang T, Düster R, Geyer M, Sim T, Marto JA, Sorger PK, Westover KD, Lin CY, Kwiatkowski N, Gray NS.
Cell Chem Biol
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Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains.
Authors: Authors: Wang J, Erazo T, Ferguson FM, Buckley DL, Gomez N, Muñoz-Guardiola P, Diéguez-Martínez N, Deng X, Hao M, Massefski W, Fedorov O, Offei-Addo NK, Park PM, Dai L, DiBona A, Becht K, Kim ND, McKeown MR, Roberts JM, Zhang J, Sim T, Alessi DR, Bradner JE, Lizcano JM, Blacklow SC, Qi J, Xu X, Gray NS.
ACS Chem Biol
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Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8.
Authors: Authors: Hatcher JM, Wang ES, Johannessen L, Kwiatkowski N, Sim T, Gray NS.
ACS Med Chem Lett
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Crystal structure of human IRAK1.
Authors: Authors: Wang L, Qiao Q, Ferrao R, Shen C, Hatcher JM, Buhrlage SJ, Gray NS, Wu H.
Proc Natl Acad Sci U S A
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Gemcitabine and Chk1 Inhibitor AZD7762 Synergistically Suppress the Growth of Lkb1-Deficient Lung Adenocarcinoma.
Authors: Authors: Liu Y, Li Y, Wang X, Liu F, Gao P, Quinn MM, Li F, Merlino AA, Benes C, Liu Q, Gray NS, Wong KK.
Cancer Res
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THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors.
Authors: Authors: Cayrol F, Praditsuktavorn P, Fernando TM, Kwiatkowski N, Marullo R, Calvo-Vidal MN, Phillip J, Pera B, Yang SN, Takpradit K, Roman L, Gaudiano M, Crescenzo R, Ruan J, Inghirami G, Zhang T, Cremaschi G, Gray NS, Cerchietti L.
Nat Commun
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Erk5 Is a Key Regulator of Naive-Primed Transition and Embryonic Stem Cell Identity.
Authors: Authors: Williams CA, Fernandez-Alonso R, Wang J, Toth R, Gray NS, Findlay GM.
Cell Rep
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Discovery of a Highly Potent and Selective Indenoindolone Type 1 Pan-FLT3 Inhibitor.
Authors: Authors: Hatcher JM, Weisberg E, Sim T, Stone RM, Liu S, Griffin JD, Gray NS.
ACS Med Chem Lett
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Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation.
Authors: Authors: Wilhelmsen K, Xu F, Farrar K, Tran A, Khakpour S, Sundar S, Prakash A, Wang J, Gray NS, Hellman J.
Sci Signal
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