Nathanael Gray, PhD

Nancy Lurie Marks Professor of Biological Chemistry and Molecular Pharmacology in the Field of Medical Oncology, Dana-Farber Cancer Institute
Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors.
Authors: Authors: Canning P, Tan L, Chu K, Lee SW, Gray NS, Bullock AN.
J Mol Biol
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mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin.
Authors: Authors: Kang SA, Pacold ME, Cervantes CL, Lim D, Lou HJ, Ottina K, Gray NS, Turk BE, Yaffe MB, Sabatini DM.
Science
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BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells.
Authors: Authors: Debruyne DN, Dries R, Sengupta S, Seruggia D, Gao Y, Sharma B, Huang H, Moreau L, McLane M, Day DS, Marco E, Chen T, Gray NS, Wong KK, Orkin SH, Yuan GC, Young RA, George RE.
Nature
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Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models.
Authors: Authors: Silva MC, Ferguson FM, Cai Q, Donovan KA, Nandi G, Patnaik D, Zhang T, Huang HT, Lucente DE, Dickerson BC, Mitchison TJ, Fischer ES, Gray NS, Haggarty SJ.
Elife
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First SAR Study for Overriding NRAS Mutant Driven Acute Myeloid Leukemia.
Authors: Authors: Cho H, Shin I, Ju E, Choi S, Hur W, Kim H, Hong E, Kim ND, Choi HG, Gray NS, Sim T.
J Med Chem
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The dTAG system for immediate and target-specific protein degradation.
Authors: Authors: Nabet B, Roberts JM, Buckley DL, Paulk J, Dastjerdi S, Yang A, Leggett AL, Erb MA, Lawlor MA, Souza A, Scott TG, Vittori S, Perry JA, Qi J, Winter GE, Wong KK, Gray NS, Bradner JE.
Nat Chem Biol
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YY1 Is a Structural Regulator of Enhancer-Promoter Loops.
Authors: Authors: Weintraub AS, Li CH, Zamudio AV, Sigova AA, Hannett NM, Day DS, Abraham BJ, Cohen MA, Nabet B, Buckley DL, Guo YE, Hnisz D, Jaenisch R, Bradner JE, Gray NS, Young RA.
Cell
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Progress towards a public chemogenomic set for protein kinases and a call for contributions.
Authors: Authors: Drewry DH, Wells CI, Andrews DM, Angell R, Al-Ali H, Axtman AD, Capuzzi SJ, Elkins JM, Ettmayer P, Frederiksen M, Gileadi O, Gray N, Hooper A, Knapp S, Laufer S, Luecking U, Michaelides M, Müller S, Muratov E, Denny RA, Saikatendu KS, Treiber DK, Zuercher WJ, Willson TM.
PLoS One
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Structure-Activity Relationship Study of QL47: A Broad-Spectrum Antiviral Agent.
Authors: Authors: Liang Y, de Wispelaere M, Carocci M, Liu Q, Wang J, Yang PL, Gray NS.
ACS Med Chem Lett
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Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival.
Authors: Authors: Wang Y, Begley M, Li Q, Huang HT, Lako A, Eck MJ, Gray NS, Mitchison TJ, Cantley LC, Zhao JJ.
Proc Natl Acad Sci U S A
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