Nathanael Gray, PhD

Nancy Lurie Marks Professor of Biological Chemistry and Molecular Pharmacology in the Field of Medical Oncology, Dana-Farber Cancer Institute
Crystal structure of human IRAK1.
Authors: Authors: Wang L, Qiao Q, Ferrao R, Shen C, Hatcher JM, Buhrlage SJ, Gray NS, Wu H.
Proc Natl Acad Sci U S A
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Gemcitabine and Chk1 Inhibitor AZD7762 Synergistically Suppress the Growth of Lkb1-Deficient Lung Adenocarcinoma.
Authors: Authors: Liu Y, Li Y, Wang X, Liu F, Gao P, Quinn MM, Li F, Merlino AA, Benes C, Liu Q, Gray NS, Wong KK.
Cancer Res
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THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors.
Authors: Authors: Cayrol F, Praditsuktavorn P, Fernando TM, Kwiatkowski N, Marullo R, Calvo-Vidal MN, Phillip J, Pera B, Yang SN, Takpradit K, Roman L, Gaudiano M, Crescenzo R, Ruan J, Inghirami G, Zhang T, Cremaschi G, Gray NS, Cerchietti L.
Nat Commun
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Erk5 Is a Key Regulator of Naive-Primed Transition and Embryonic Stem Cell Identity.
Authors: Authors: Williams CA, Fernandez-Alonso R, Wang J, Toth R, Gray NS, Findlay GM.
Cell Rep
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Discovery of a Highly Potent and Selective Indenoindolone Type 1 Pan-FLT3 Inhibitor.
Authors: Authors: Hatcher JM, Weisberg E, Sim T, Stone RM, Liu S, Griffin JD, Gray NS.
ACS Med Chem Lett
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Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation.
Authors: Authors: Wilhelmsen K, Xu F, Farrar K, Tran A, Khakpour S, Sundar S, Prakash A, Wang J, Gray NS, Hellman J.
Sci Signal
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Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor.
Authors: Authors: Christensen CL, Kwiatkowski N, Abraham BJ, Carretero J, Al-Shahrour F, Zhang T, Chipumuro E, Herter-Sprie GS, Akbay EA, Altabef A, Zhang J, Shimamura T, Capelletti M, Reibel JB, Cavanaugh JD, Gao P, Liu Y, Michaelsen SR, Poulsen HS, Aref AR, Barbie DA, Bradner JE, George RE, Gray NS, Young RA, Wong KK.
Cancer Cell
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Screening of DUB activity and specificity by MALDI-TOF mass spectrometry.
Authors: Authors: Ritorto MS, Ewan R, Perez-Oliva AB, Knebel A, Buhrlage SJ, Wightman M, Kelly SM, Wood NT, Virdee S, Gray NS, Morrice NA, Alessi DR, Trost M.
Nat Commun
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Interleukin-6 secretion by astrocytes is dynamically regulated by PI3K-mTOR-calcium signaling.
Authors: Authors: Codeluppi S, Fernandez-Zafra T, Sandor K, Kjell J, Liu Q, Abrams M, Olson L, Gray NS, Svensson CI, Uhlén P.
PLoS One
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Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells.
Authors: Authors: Taipale M, Krykbaeva I, Whitesell L, Santagata S, Zhang J, Liu Q, Gray NS, Lindquist S.
Nat Biotechnol
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