Pamela Silver, PhD
Elliott T. and Onie H. Adams Professor of Biochemistry and Systems Biology, Harvard Medical School
Designing biological systems.
Pore-ing the right dose.
Class II integrase mutants with changes in putative nuclear localization signals are primarily blocked at a postnuclear entry step of human immunodeficiency virus type 1 replication.
Authors: Authors: Lu R, Limón A, Devroe E, Silver PA, Cherepanov P, Engelman A.
J Virol
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J Virol
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Intracellular transport of human immunodeficiency virus type 1 integrase.
Identifying proteins that affect mRNA localization in living cells.
Diverse nuclear transport pathways regulate cell proliferation and oncogenesis.
Interactions between a nuclear transporter and a subset of nuclear pore complex proteins depend on Ran GTPase.
Authors: Authors: Seedorf M, Damelin M, Kahana J, Taura T, Silver PA.
Mol Cell Biol
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Mol Cell Biol
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Hrp1, a sequence-specific RNA-binding protein that shuttles between the nucleus and the cytoplasm, is required for mRNA 3'-end formation in yeast.
Authors: Authors: Kessler MM, Henry MF, Shen E, Zhao J, Gross S, Silver PA, Moore CL.
Genes Dev
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Genes Dev
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Mutants in a yeast Ran binding protein are defective in nuclear transport.
Movement of macromolecules between the cytoplasm and the nucleus in yeast.